Toward a primate model of l-dopa-unresponsive parkinsonism mimicking striatonigral degeneration

We developed a primate model of striatonigral degeneration (SND), the neuropathology underlying levodopa‐unresponsive parkinsonism associated with multiple systemic atrophy (MSA‐P), by sequential systemic administration of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) and 3‐nitropropionic acid...

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Veröffentlicht in:	Movement disorders Jg. 15; H. 3; S. 531 - 536
Hauptverfasser:	Ghorayeb, Imad, Fernagut, Pierre O., Aubert, Incarnation, Bezard, Erwan, Poewe, Werner, Wenning, Gregor K., Tison, François
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York John Wiley & Sons, Inc 01.05.2000 Wiley
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Antiparkinson Agents - pharmacology Biological and medical sciences Brain Mapping Corpus Striatum - drug effects Corpus Striatum - pathology Corpus Striatum - physiopathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diagnosis, Differential Disease Models, Animal Dopamine - metabolism Levodopa - pharmacology Macaca fascicularis Male Medical sciences MPTP-3 nitropropionic acid Multiple system atrophy Multiple System Atrophy - chemically induced Multiple System Atrophy - pathology Multiple System Atrophy - physiopathology Nerve Degeneration - chemically induced Nerve Degeneration - pathology Nerve Degeneration - physiopathology Neurology Neurotoxins Nitro Compounds Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - pathology Parkinson Disease, Secondary - physiopathology Parkinsonism Primate model Primates Propionates Striatonigral degeneration Striatonigral Degeneration - chemically induced Striatonigral Degeneration - pathology Striatonigral Degeneration - physiopathology Animal model Nervous system diseases Pathophysiology Monkey Cerebral disorder Parkinsonism Vertebrata Mammalia Animal Central nervous system disease Primates Multiple system atrophy Degenerative disease Nigrostriatal pathway
ISSN:	0885-3185, 1531-8257
Online-Zugang:	Volltext
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