Restriction fragment length polymorphism effectively identifies exon 1 mutation of UGT1A1 gene in patients with Gilbert's Syndrome

Background & Aims Gilbert's syndrome causes pharmacological variation in drug glucuronidation and unexpected toxicity from therapeutic agents. The two common genotypes of Gilbert's syndrome are a dinucleotide polymorphism (TA)7 in TATA‐Box as well as the 211G>A mutation in the codin...

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Vydáno v:	Liver international Ročník 35; číslo 8; s. 2050 - 2056
Hlavní autoři:	Shiu, Tzu-Yue, Huang, Hsin-Hung, Lin, Hsuan-Hwai, Shih, Yu-Lueng, Chu, Heng-Cheng, Chang, Wei-Kuo, Hsieh, Tsai-Yuan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Blackwell Publishing Ltd 01.08.2015
Témata:	Asian Continental Ancestry Group - genetics Child Cohort Studies exon Exons - genetics Female Genetic Predisposition to Disease - epidemiology Genotype Gilbert Disease - diagnosis Gilbert Disease - epidemiology Gilbert Disease - genetics Gilbert's syndrome Glucuronosyltransferase - genetics Humans Incidence Male Mutation Polymorphism, Restriction Fragment Length - genetics Promoter Regions, Genetic - genetics restriction fragment length polymorphism Retrospective Studies Taiwan - epidemiology UDP-glucuronosyltransferase 1A1 Taiwan mutation restriction fragment length polymorphism Gilbert's syndrome exon UDP-glucuronosyltransferase 1A1
ISSN:	1478-3223, 1478-3231, 1478-3231
On-line přístup:	Získat plný text
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