Vitamin D's role in cell proliferation and differentiation

Vitamin D has pleiotropic effects that go beyond its traditional role in calcium homeostasis. Hundreds of genes with vitamin D receptor response elements directly or indirectly influence cell cycling and proliferation, differentiation, and apoptosis. Vitamin D compounds also have effects on cell fun...

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Veröffentlicht in:Nutrition reviews Jg. 66; H. s2; S. S116 - S124
Hauptverfasser: Samuel, Sam, Sitrin, Michael D
Format: Journal Article Tagungsbericht
Sprache:Englisch
Veröffentlicht: Malden, USA Blackwell Publishing Inc 01.10.2008
Wiley
Oxford University Press
Schlagworte:
apoptosis
Apoptosis - drug effects
Biological and medical sciences
calcitriol
Calcium
Calcium - metabolism
Carcinogenesis
Cell cycle
Cell Differentiation - drug effects
Cell Differentiation - physiology
Cell division
Cell Division - drug effects
Cell Division - physiology
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Genes
Humans
hyperplasia
Immune response
Neoplasms - prevention & control
Receptors, Calcitriol - metabolism
Receptors, Calcitriol - physiology
signal transduction
Signal Transduction - drug effects
transcription factors
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin D
Vitamin D - physiology
Cell proliferation
Signal transduction
Vertebrata
Mammalia
Vitamin D
transcription factors
Hyperplasia
Cell cycle
Cell differentiation
Transcription factor
Apoptosis
calcitriol cell cycle
ISSN:0029-6643, 1753-4887, 1753-4887
Online-Zugang:Volltext
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Zusammenfassung:Vitamin D has pleiotropic effects that go beyond its traditional role in calcium homeostasis. Hundreds of genes with vitamin D receptor response elements directly or indirectly influence cell cycling and proliferation, differentiation, and apoptosis. Vitamin D compounds also have effects on cell function that are nongenomic. The noncalcemic actions of vitamin D influence normal and pathological cell growth, carcinogenesis, immune function, and cardiovascular physiology. This review examines many of the various mechanisms by which vitamin D alters cellular growth and differentiation and explores cell‐specific factors that influence responsiveness to vitamin D.
Bibliographie:istex:6816B29F661B32180D376E732D708A5C500B7221
ark:/67375/WNG-R5FT0DCR-7
ArticleID:NURE094
ObjectType-Article-1
SourceType-Scholarly Journals-1
content type line 14
ObjectType-Literature Review-2
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:0029-6643
1753-4887
1753-4887
DOI:10.1111/j.1753-4887.2008.00094.x