Vitamin D's role in cell proliferation and differentiation

Vitamin D has pleiotropic effects that go beyond its traditional role in calcium homeostasis. Hundreds of genes with vitamin D receptor response elements directly or indirectly influence cell cycling and proliferation, differentiation, and apoptosis. Vitamin D compounds also have effects on cell fun...

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Vydané v:	Nutrition reviews Ročník 66; číslo s2; s. S116 - S124
Hlavní autori:	Samuel, Sam, Sitrin, Michael D
Médium:	Journal Article Konferenčný príspevok..
Jazyk:	English
Vydavateľské údaje:	Malden, USA Blackwell Publishing Inc 01.10.2008 Wiley Oxford University Press
Predmet:	apoptosis Apoptosis - drug effects Biological and medical sciences calcitriol Calcium Calcium - metabolism Carcinogenesis Cell cycle Cell Differentiation - drug effects Cell Differentiation - physiology Cell division Cell Division - drug effects Cell Division - physiology Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Genes Humans hyperplasia Immune response Neoplasms - prevention & control Receptors, Calcitriol - metabolism Receptors, Calcitriol - physiology signal transduction Signal Transduction - drug effects transcription factors Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin D Vitamin D - physiology Cell proliferation Signal transduction Vertebrata Mammalia Vitamin D transcription factors Hyperplasia Cell cycle Cell differentiation Transcription factor Apoptosis calcitriol cell cycle
ISSN:	0029-6643, 1753-4887, 1753-4887
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Abstract	Vitamin D has pleiotropic effects that go beyond its traditional role in calcium homeostasis. Hundreds of genes with vitamin D receptor response elements directly or indirectly influence cell cycling and proliferation, differentiation, and apoptosis. Vitamin D compounds also have effects on cell function that are nongenomic. The noncalcemic actions of vitamin D influence normal and pathological cell growth, carcinogenesis, immune function, and cardiovascular physiology. This review examines many of the various mechanisms by which vitamin D alters cellular growth and differentiation and explores cell‐specific factors that influence responsiveness to vitamin D.
AbstractList	Vitamin D has pleiotropic effects that go beyond its traditional role in calcium homeostasis. Hundreds of genes with vitamin D receptor response elements directly or indirectly influence cell cycling and proliferation, differentiation, and apoptosis. Vitamin D compounds also have effects on cell function that are nongenomic. The noncalcemic actions of vitamin D influence normal and pathological cell growth, carcinogenesis, immune function, and cardiovascular physiology. This review examines many of the various mechanisms by which vitamin D alters cellular growth and differentiation and explores cell-specific factors that influence responsiveness to vitamin D.Vitamin D has pleiotropic effects that go beyond its traditional role in calcium homeostasis. Hundreds of genes with vitamin D receptor response elements directly or indirectly influence cell cycling and proliferation, differentiation, and apoptosis. Vitamin D compounds also have effects on cell function that are nongenomic. The noncalcemic actions of vitamin D influence normal and pathological cell growth, carcinogenesis, immune function, and cardiovascular physiology. This review examines many of the various mechanisms by which vitamin D alters cellular growth and differentiation and explores cell-specific factors that influence responsiveness to vitamin D. Vitamin D has pleiotropic effects that go beyond its traditional role in calcium homeostasis. Hundreds of genes with vitamin D receptor response elements directly or indirectly influence cell cycling and proliferation, differentiation, and apoptosis. Vitamin D compounds also have effects on cell function that are nongenomic. The noncalcemic actions of vitamin D influence normal and pathological cell growth, carcinogenesis, immune function, and cardiovascular physiology. This review examines many of the various mechanisms by which vitamin D alters cellular growth and differentiation and explores cell-specific factors that influence responsiveness to vitamin D. [PUBLICATION ABSTRACT] Vitamin D has pleiotropic effects that go beyond its traditional role in calcium homeostasis. Hundreds of genes with vitamin D receptor response elements directly or indirectly influence cell cycling and proliferation, differentiation, and apoptosis. Vitamin D compounds also have effects on cell function that are nongenomic. The noncalcemic actions of vitamin D influence normal and pathological cell growth, carcinogenesis, immune function, and cardiovascular physiology. This review examines many of the various mechanisms by which vitamin D alters cellular growth and differentiation and explores cell‐specific factors that influence responsiveness to vitamin D.
Author	Sitrin, Michael D Samuel, Sam
Author_xml	– sequence: 1 givenname: Sam surname: Samuel fullname: Samuel, Sam organization: The Western New York Veterans Administration Medical Center, University at Buffalo, State University of New York, Buffalo, New York, USA – sequence: 2 givenname: Michael D surname: Sitrin fullname: Sitrin, Michael D email: michael.sitrin@med.va.gov organization: The Western New York Veterans Administration Medical Center, University at Buffalo, State University of New York, Buffalo, New York, USA
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Keywords	Cell proliferation Signal transduction Vertebrata Mammalia Vitamin D transcription factors Hyperplasia Cell cycle Cell differentiation Transcription factor Apoptosis calcitriol cell cycle
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Snippet	Vitamin D has pleiotropic effects that go beyond its traditional role in calcium homeostasis. Hundreds of genes with vitamin D receptor response elements...
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SubjectTerms	apoptosis Apoptosis - drug effects Biological and medical sciences calcitriol Calcium Calcium - metabolism Carcinogenesis Cell cycle Cell Differentiation - drug effects Cell Differentiation - physiology Cell division Cell Division - drug effects Cell Division - physiology Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Genes Humans hyperplasia Immune response Neoplasms - prevention & control Receptors, Calcitriol - metabolism Receptors, Calcitriol - physiology signal transduction Signal Transduction - drug effects transcription factors Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin D Vitamin D - physiology
Title	Vitamin D's role in cell proliferation and differentiation
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