Interaction between Vitamin D and calcium

Abstract A low calcium intake aggravates the consequences of vitamin D deficiency. This suggests an interaction between vitamin D and calcium intake, which is the subject of this review. The active vitamin D metabolite, 1,25-dihydroxyvitamin D (1,25(OH)2D) binds to the vitamin D receptor (VDR) in th...

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Vydáno v:Scandinavian journal of clinical & laboratory investigation. Supplement Ročník 72; číslo S243; s. 60 - 64
Hlavní autor: Lips, Paul
Médium: Journal Article
Jazyk:angličtina
Vydáno: Colchester Informa Healthcare 01.04.2012
Taylor & Francis
Informa
Témata:
Absorption
Animals
Biological and medical sciences
Calcium - metabolism
Calcium, Dietary - administration & dosage
Clinical Trials as Topic
Humans
Hyperparathyroidism, Secondary - prevention & control
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Mice
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D - metabolism
Calcium
Vitamin D
Inorganic element
Interaction
Clinical biology
ISSN:0036-5513, 2166-1030, 1502-7686, 2166-1030
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Shrnutí:Abstract A low calcium intake aggravates the consequences of vitamin D deficiency. This suggests an interaction between vitamin D and calcium intake, which is the subject of this review. The active vitamin D metabolite, 1,25-dihydroxyvitamin D (1,25(OH)2D) binds to the vitamin D receptor (VDR) in the intestinal cell and stimulates the active calcium transport from the intestine to the circulation. Vitamin D is not needed for the paracellular transport of calcium, which depends on the calcium gradient. Active calcium absorption decreases when the serum 25-hydroxyvitamin D (25(OH)D) concentration is < 20 nmol/L. Studies in the VDR null mouse have demonstrated that bone mineralisation can be restored without vitamin D by a diet very high in calcium and lactose. Both calcium and vitamin D metabolites can decrease the secretion of parathyroid hormone (PTH) through the calcium sensing receptor and the VDR respectively. With an increasing serum 25(OH)D concentration up to 100 nmol/L or higher serum PTH is still decreasing. A high calcium intake increases the half life of 25(OH)D. In patients with primary or secondary hyperparathyroidism, the half life of 25(OH)D is shorter. Similar interactions between calcium intake and vitamin D status have been shown in rat experiments, generally indicating that a high calcium intake is good for the vitamin D economy. Clinical trials with vitamin D and/or calcium to decrease fracture incidence generally have shown that trials with vitamin D and calcium had better results than calcium or vitamin D alone. The effects of these trials also depend on baseline calcium intake, baseline vitamin D status, age and residence. Trials in institutionalized persons had better results than in independently living elderly. These results confirm that an interaction exists between calcium and vitamin D.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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ISSN:0036-5513
2166-1030
1502-7686
2166-1030
DOI:10.3109/00365513.2012.681960