Tumour cell dissemination following endoscopic stent insertion

Background: This study examined whether colonoscopy or endoscopic stent insertion increases levels of carcinoembryonic antigen (CEA) and/or cytokeratin (CK) 20 mRNA expression in the peripheral circulation of patients with colorectal cancer. Methods: Peripheral venous blood samples were obtained bef...

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Bibliographic Details
Published in:British journal of surgery Vol. 94; no. 9; pp. 1151 - 1154
Main Authors: Maruthachalam, K., Lash, G. E., Shenton, B. K., Horgan, A. F.
Format: Journal Article
Language:English
Published: Chichester, UK John Wiley & Sons, Ltd 01.09.2007
Wiley
Subjects:
Biological and medical sciences
Biomarkers, Tumor - blood
Carcinoembryonic Antigen - blood
Case-Control Studies
Colonoscopy
Colorectal Neoplasms - surgery
Endoscopy
General aspects
Humans
Keratin-20 - blood
Medical sciences
Neoplastic Cells, Circulating - metabolism
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - blood
Stents - adverse effects
Medicine
Endoprosthesis
Endoscopic route
Surgery
Dissemination
Instrumentation therapy
Stent
Tumor cell
ISSN:0007-1323, 1365-2168
Online Access:Get full text
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Summary:Background: This study examined whether colonoscopy or endoscopic stent insertion increases levels of carcinoembryonic antigen (CEA) and/or cytokeratin (CK) 20 mRNA expression in the peripheral circulation of patients with colorectal cancer. Methods: Peripheral venous blood samples were obtained before and after colonoscopy (38 patients) or colonic stent insertion (20). Twenty patients undergoing colonoscopy for benign conditions served as controls. Expression of mRNA was quantified using real‐time reverse transcriptase–polymerase chain reaction. Results: Circulating CK20 mRNA was detected in 13 of 38 patients who had a colonoscopy and eight of 20 patients with stent insertion. CK20 mRNA expression was increased following stent insertion (P = 0·007) but not after staging colonoscopy (P = 0·454). CEA mRNA was detected in one patient who had colonoscopy and two who had a stent inserted. Neither CEA nor CK20 mRNA was found in blood samples from controls. Conclusion: Endoscopic insertion of colonic stents but not staging colonoscopy results in increased levels of CK20 mRNA in the peripheral circulation. Copyright © 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. May shed tumour cells or particles
Bibliography:ark:/67375/WNG-MG4J3KZ0-H
ArticleID:BJS5790
Presented to meetings of the American Society of Colon and Rectal Surgeons, Philadelphia, Pennsylvania, USA, April 2005, the British Association of Surgical Oncology, London, UK, November 2005, and the Association of Coloproctology of Great Britain and Ireland, Newcastle upon Tyne, UK, July 2006
istex:FAA56E9508D69F0936C3AC71F9308BC34684C839
Department of Coloproctology, Newcastle upon Tyne, UK
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-1323
1365-2168
DOI:10.1002/bjs.5790