Hydrophobic and electrostatic interactions between cell penetrating peptides and plasmid DNA are important for stable non-covalent complexation and intracellular delivery

Cell penetrating peptides are useful tools for intracellular delivery of nucleic acids. Delivery of plasmid DNA, a large nucleic acid, poses a challenge for peptide mediated transport. The paper investigates and compares efficacy of five novel peptide designs for complexation of plasmid DNA and subs...

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Bibliographic Details
Published in:	Journal of peptide science Vol. 22; no. 10; pp. 647 - 659
Main Authors:	Upadhya, Archana, Sangave, Preeti C.
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01.10.2016 Wiley Subscription Services, Inc
Subjects:	Alkaline Phosphatase - genetics Alkaline Phosphatase - secretion Amino Acid Sequence Animals cell penetrating peptides Cell Survival - drug effects Cell-Penetrating Peptides - chemistry Cell-Penetrating Peptides - metabolism Cell-Penetrating Peptides - pharmacology Cytotoxicity Deoxyribonuclease I - chemistry Deoxyribonucleic acid DNA DNA - chemistry DNA - metabolism Erythrocytes - drug effects gene delivery Gene Expression Genes, Reporter HeLa Cells Hemolysis - drug effects Humans Hydrophobic and Hydrophilic Interactions hydrophobic interaction membrane translocating sequence Mice NIH 3T3 Cells noncovalent complexation Nucleic acids Peptides Plasmids - chemistry Plasmids - metabolism Protein Binding Rats Static Electricity stearylated octa-arginine Transfection - methods gene delivery cell penetrating peptides stearylated octa-arginine hydrophobic interaction noncovalent complexation membrane translocating sequence
ISSN:	1075-2617, 1099-1387, 1099-1387
Online Access:	Get full text
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