Genetic susceptibility to type 1 diabetes in childhood - estimation of HLA class II associated disease risk and class II effect in various phases of islet autoimmunity

Objective The HLA‐DR/DQ region remains the major determinant of susceptibility to type 1 diabetes (T1D) despite the more than 50 risk affecting loci outside human leukocyte antigen (HLA) region that have been identified. We aimed at developing a simple risk estimation based on HLA class II genotypin...

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Veröffentlicht in:	Pediatric diabetes Jg. 17; H. S22; S. 8 - 16
Hauptverfasser:	Ilonen, J, Kiviniemi, M, Lempainen, J, Simell, O, Toppari, J, Veijola, R, Knip, M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Former Munksgaard John Wiley & Sons A/S 01.07.2016
Schlagworte:	Adult Autoimmunity Case-Control Studies Child Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - immunology Female Genes, MHC Class II Genetic Predisposition to Disease genetics Haplotypes HLA class II Humans islet autoimmunity Islets of Langerhans - immunology Male Risk Assessment type 1 diabetes HLA class II type 1 diabetes genetics islet autoimmunity
ISSN:	1399-543X, 1399-5448, 1399-5448
Online-Zugang:	Volltext
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