The role of microbial biofilms in prosthetic joint infections

Abstract - Prosthetic joint infection (PJI) still remains a significant problem. In line with the forecasted rise in joint replacement procedures, the number of cases of PJI is also anticipated to rise. The formation of biofilm by causative pathogens is central to the occurrence and the recalcitranc...

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Bibliographic Details
Published in:	Acta orthopaedica Vol. 86; no. 2; pp. 147 - 158
Main Authors:	Gbejuade, Herbert O, Lovering, Andrew M, Webb, Jason C
Format:	Journal Article
Language:	English
Published:	England Nordic Orthopaedic Federation 01.04.2015
Subjects:	Anti-Bacterial Agents - therapeutic use Bacteriophages - growth & development Biofilms Deoxyribonuclease I - therapeutic use Humans Joint Prosthesis - adverse effects Prosthesis-Related Infections - diagnosis Prosthesis-Related Infections - microbiology Prosthesis-Related Infections - therapy
ISSN:	1745-3674, 1745-3682, 1745-3682
Online Access:	Get full text
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Summary:	Abstract - Prosthetic joint infection (PJI) still remains a significant problem. In line with the forecasted rise in joint replacement procedures, the number of cases of PJI is also anticipated to rise. The formation of biofilm by causative pathogens is central to the occurrence and the recalcitrance of PJI. The subject of microbial biofilms is receiving increasing attention, probably as a result of the wide acknowledgement of the ubiquity of biofilms in the natural, industrial, and clinical contexts, as well as the notorious difficulty in eradicating them. In this review, we discuss the pertinent issues surrounding PJI and the challenges posed by biofilms regarding diagnosis and treatment. In addition, we discuss novel strategies of prevention and treatment of biofilm-related PJI.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1745-3674 1745-3682 1745-3682
DOI:	10.3109/17453674.2014.966290