Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia

Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa therapy for Parkinson's disease. Although changes affecting D1 and D2 dopamine receptors have been studied in association with this condition, no causal relationship has yet been established. Taking advantag...

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Bibliographic Details
Published in:	Annals of neurology Vol. 57; no. 1; pp. 17 - 26
Main Authors:	Aubert, Incarnation, Guigoni, Céline, Håkansson, Kerstin, Li, Qin, Dovero, Sandra, Barthe, Nicole, Bioulac, Bernard H., Gross, Christian E., Fisone, Gilberto, Bloch, Bertrand, Bezard, Erwan
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.01.2005 Willey-Liss
Subjects:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology Analysis of Variance Animals Antiparkinson Agents - adverse effects Autoradiography - methods Behavior, Animal Biological and medical sciences Blotting, Western - methods Cyclin-Dependent Kinase 5 Cyclin-Dependent Kinases Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Dopamine and cAMP-Regulated Phosphoprotein 32 Dopamine Plasma Membrane Transport Proteins Dose-Response Relationship, Drug Drug Interactions Drug toxicity and drugs side effects treatment Dyskinesia, Drug-Induced - etiology Dyskinesia, Drug-Induced - metabolism Female Guanosine 5'-O-(3-Thiotriphosphate) - pharmacokinetics Immunohistochemistry - methods In Situ Hybridization - methods Isotopes - pharmacokinetics Levodopa - adverse effects Macaca fascicularis Medical sciences Membrane Glycoproteins - metabolism Membrane Transport Proteins - metabolism Motor Activity - drug effects Nerve Tissue Proteins - metabolism Neurology Nortropanes - pharmacokinetics Parkinsonian Disorders - drug therapy Parkinsonian Disorders - metabolism Parkinsonian Disorders - physiopathology Pharmacology. Drug treatments Phosphoproteins - metabolism Radioligand Assay - methods Receptors, Dopamine D1 - agonists Receptors, Dopamine D1 - genetics Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - genetics Receptors, Dopamine D2 - metabolism Signal Transduction - drug effects Substantia Nigra - drug effects Substantia Nigra - metabolism Time Factors Toxicity: nervous system and muscle Tyrosine 3-Monooxygenase - metabolism Signal transduction Nervous system diseases Central nervous system disease D1 Dopamine receptor Levodopa Neurological disorder Antiparkinson agent Motor control Cerebral disorder Extrapyramidal syndrome Involuntary movement Dyskinesia
ISSN:	0364-5134, 1531-8249
Online Access:	Get full text
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