Using claims data to predict dependency in activities of daily living as a proxy for frailty

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Vydáno v:Pharmacoepidemiology and drug safety Ročník 24; číslo 1; s. 59 - 66
Hlavní autoři: Faurot, Keturah R., Jonsson Funk, Michele, Pate, Virginia, Brookhart, M. Alan, Patrick, Amanda, Hanson, Laura C., Castillo, Wendy Camelo, Stürmer, Til
Médium: Journal Article
Jazyk:angličtina
Vydáno: Blackwell Publishing Ltd 01.01.2015
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ISSN:1053-8569, 1099-1557
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Author Jonsson Funk, Michele
Faurot, Keturah R.
Castillo, Wendy Camelo
Brookhart, M. Alan
Hanson, Laura C.
Pate, Virginia
Stürmer, Til
Patrick, Amanda
AuthorAffiliation 2 Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill
4 Division of Geriatric Medicine, School of Medicine, University of North Carolina at Chapel Hill
5 Pharmaceutical Health Services Research, School of Pharmacy, University of Maryland
1 Department of Physical Medicine and Rehabilitation, School of Medicine, University of North Carolina at Chapel Hill
3 Division of Pharmacoepidemiology, Brigham and Women’s Hospital
AuthorAffiliation_xml – name: 1 Department of Physical Medicine and Rehabilitation, School of Medicine, University of North Carolina at Chapel Hill
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  organization: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, NC, Chapel Hill, USA
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  organization: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, NC, Chapel Hill, USA
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  surname: Patrick
  fullname: Patrick, Amanda
  organization: Division of Pharmacoepidemiology, Brigham and Women's Hospital, MA, Boston, USA
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  surname: Hanson
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  organization: Division of Geriatric Medicine, School of Medicine, University of North Carolina, NC, Chapel Hill, USA
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  givenname: Wendy Camelo
  surname: Castillo
  fullname: Castillo, Wendy Camelo
  organization: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
– sequence: 8
  givenname: Til
  surname: Stürmer
  fullname: Stürmer, Til
  organization: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, NC, Chapel Hill, USA
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Notes Supporting info item
Versions of this work were presented at the International Conference on Pharmacoepidemiology & Therapeutic Risk Management in 2012 and 2013. Related work was also presented at the 2012 Scientific Meeting of the Gerontological Society of America.
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References Fried LP, Ferrucci L, Darer J, et al. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 2004; 59(3): 255-63.
Groenwold RH, Hoes AW, Hak E. Impact of influenza vaccination on mortality risk among the elderly. Eur Respir J 2009; 34(1): 56-62. doi:10.1183/09031936.00190008.
Kim DH and Schneeweiss S. Measuring frailty using claims data for pharmacoepidemiologic studies of mortality in older adults: evidence and recommendations. Pharmacoepidemiol Drug Saf 2014 Jun 24; DOI: 10.1002/pds.3674.
Ensrud KE, Ewing SK, Taylor BC, et al. Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. Arch Intern Med 2008; 168(4): 382-9. doi:10.1001/archinternmed.2007.113.
Boyd CM, Xue QL, Simpson CF, et al. Frailty, hospitalization, and progression of disability in a cohort of disabled older women. Am J Med 2005; 118(11): 1225-31. doi:10.1016/j.amjmed.2005.01.062.
Katz S, Downs TD, Cash HR, et al. Progress in development of the index of ADL. Gerontologist 1970; 10(1): 20-30.
Glynn RJ, Schneeweiss S, Wang PS, et al. Selective prescribing led to overestimation of the benefits of lipid-lowering drugs. J Clin Epidemiol 2006; 59(8): 819-28. doi:10.1016/j.jclinepi.2005.12.012.
Searle SD, Mitnitski A, Gahbauer EA, et al. A standard procedure for creating a frailty index. BMC Geriatr 2008; 8: 24. doi:10.1186/1471-2318-8-24.
Davidoff AJ, Zuckerman IH, Pandya N, et al. A novel approach to improve health status measurement in observational claims-based studies of cancer treatment and outcomes. Journal of geriatric oncology 2013; 4(2): 157-65. doi:10.1016/j.jgo.2012.12.005.
Rockwood K, Hogan DB, MacKnight C. Conceptualisation and measurement of frailty in elderly people. Drugs Aging 2000; 17(4): 295-302.
Keeler E, Guralnik JM, Tian H, et al. The impact of functional status on life expectancy in older persons. J Gerontol A Biol Sci Med Sci 2010; 65(7): 727-33. doi:10.1093/gerona/glq029.
Groenwold RH, Hak E, Klungel OH, et al. Instrumental variables in influenza vaccination studies: mission impossible?!. Value Health 2010; 13(1): 132-7. doi:10.1111/j.1524-4733.2009.00584.x.
Groenwold RH, Nelson DB, Nichol KL, et al. Sensitivity analyses to estimate the potential impact of unmeasured confounding in causal research. Int J Epidemiol 2010; 39(1): 107-17. doi:10.1093/ije/dyp332.
Setoguchi S, Glynn RJ, Avorn J, et al. Statins and the risk of lung, breast, and colorectal cancer in the elderly. Circulation 2007; 115(1): 27-33. doi:10.1161/CIRCULATIONAHA.106.650176.
Ray WA, Daugherty JR, Griffin MR. Lipid-lowering agents and the risk of hip fracture in a Medicaid population. Inj Prev 2002; 8(4): 276-9.
Nichol KL, Nordin JD, Nelson DB, et al. Effectiveness of influenza vaccine in the community-dwelling elderly. N Engl J Med 2007; 357(14): 1373-81. doi:10.1056/NEJMoa070844.
Stürmer T, Jonsson Funk M, Poole C, et al. Nonexperimental comparative effectiveness research using linked healthcare databases. Epidemiology 2011; 22(3): 298-301. doi:10.1097/EDE.0b013e318212640c.
Walter LC, Brand RJ, Counsell SR, et al. Development and validation of a prognostic index for 1-year mortality in older adults after hospitalization. JAMA 2001; 285(23): 2987-94.
Noyes K, Liu H, Holloway R, et al. Accuracy of Medicare claims data in identifying Parkinsonism cases: comparison with the Medicare current beneficiary survey. Movement disorders : official journal of the Movement Disorder Society 2007; 22(4): 509-14. doi:10.1002/mds.21299.
Stürmer T, Rothman KJ, Avorn J, et al. Treatment effects in the presence of unmeasured confounding: dealing with observations in the tails of the propensity score distribution--a simulation study. Am J Epidemiol 2010; 172(7): 843-54. doi:10.1093/aje/kwq198.
Woods NF, LaCroix AZ, Gray SL, et al. Frailty: emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study. J Am Geriatr Soc 2005; 53(8): 1321-30. doi:10.1111/j.1532-5415.2005.53405.x.
Jackson ML, Yu O, Nelson JC, et al. Further evidence for bias in observational studies of influenza vaccine effectiveness: the 2009 influenza A(H1N1) pandemic. Am J Epidemiol 2013; 178(8): 1327-36. doi:10.1093/aje/kwt124.
Avila-Funes JA, Amieva H, Barberger-Gateau P, et al. Cognitive impairment improves the predictive validity of the phenotype of frailty for adverse health outcomes: the three-city study. J Am Geriatr Soc 2009; 57(3): 453-61. doi:10.1111/j.1532-5415.2008.02136.x.
Jackson LA, Nelson JC, Benson P, et al. Functional status is a confounder of influenza vaccine and risk of all cause mortality in seniors. Int J Epidemiol 2006; 35(2): 345-352. doi:10.1093/ije/dyi274.
Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56(3): M146-56.
Dormuth CR, Patrick AR, Shrank WH, et al. Statin adherence and risk of accidents: a cautionary tale. Circulation 2009; 119(15): 2051-7. doi:10.1161/CIRCULATIONAHA.108.824151.
References_xml – reference: Groenwold RH, Hoes AW, Hak E. Impact of influenza vaccination on mortality risk among the elderly. Eur Respir J 2009; 34(1): 56-62. doi:10.1183/09031936.00190008.
– reference: Groenwold RH, Hak E, Klungel OH, et al. Instrumental variables in influenza vaccination studies: mission impossible?!. Value Health 2010; 13(1): 132-7. doi:10.1111/j.1524-4733.2009.00584.x.
– reference: Stürmer T, Rothman KJ, Avorn J, et al. Treatment effects in the presence of unmeasured confounding: dealing with observations in the tails of the propensity score distribution--a simulation study. Am J Epidemiol 2010; 172(7): 843-54. doi:10.1093/aje/kwq198.
– reference: Woods NF, LaCroix AZ, Gray SL, et al. Frailty: emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study. J Am Geriatr Soc 2005; 53(8): 1321-30. doi:10.1111/j.1532-5415.2005.53405.x.
– reference: Fried LP, Ferrucci L, Darer J, et al. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 2004; 59(3): 255-63.
– reference: Kim DH and Schneeweiss S. Measuring frailty using claims data for pharmacoepidemiologic studies of mortality in older adults: evidence and recommendations. Pharmacoepidemiol Drug Saf 2014 Jun 24; DOI: 10.1002/pds.3674.
– reference: Glynn RJ, Schneeweiss S, Wang PS, et al. Selective prescribing led to overestimation of the benefits of lipid-lowering drugs. J Clin Epidemiol 2006; 59(8): 819-28. doi:10.1016/j.jclinepi.2005.12.012.
– reference: Katz S, Downs TD, Cash HR, et al. Progress in development of the index of ADL. Gerontologist 1970; 10(1): 20-30.
– reference: Groenwold RH, Nelson DB, Nichol KL, et al. Sensitivity analyses to estimate the potential impact of unmeasured confounding in causal research. Int J Epidemiol 2010; 39(1): 107-17. doi:10.1093/ije/dyp332.
– reference: Keeler E, Guralnik JM, Tian H, et al. The impact of functional status on life expectancy in older persons. J Gerontol A Biol Sci Med Sci 2010; 65(7): 727-33. doi:10.1093/gerona/glq029.
– reference: Davidoff AJ, Zuckerman IH, Pandya N, et al. A novel approach to improve health status measurement in observational claims-based studies of cancer treatment and outcomes. Journal of geriatric oncology 2013; 4(2): 157-65. doi:10.1016/j.jgo.2012.12.005.
– reference: Stürmer T, Jonsson Funk M, Poole C, et al. Nonexperimental comparative effectiveness research using linked healthcare databases. Epidemiology 2011; 22(3): 298-301. doi:10.1097/EDE.0b013e318212640c.
– reference: Avila-Funes JA, Amieva H, Barberger-Gateau P, et al. Cognitive impairment improves the predictive validity of the phenotype of frailty for adverse health outcomes: the three-city study. J Am Geriatr Soc 2009; 57(3): 453-61. doi:10.1111/j.1532-5415.2008.02136.x.
– reference: Setoguchi S, Glynn RJ, Avorn J, et al. Statins and the risk of lung, breast, and colorectal cancer in the elderly. Circulation 2007; 115(1): 27-33. doi:10.1161/CIRCULATIONAHA.106.650176.
– reference: Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56(3): M146-56.
– reference: Ray WA, Daugherty JR, Griffin MR. Lipid-lowering agents and the risk of hip fracture in a Medicaid population. Inj Prev 2002; 8(4): 276-9.
– reference: Dormuth CR, Patrick AR, Shrank WH, et al. Statin adherence and risk of accidents: a cautionary tale. Circulation 2009; 119(15): 2051-7. doi:10.1161/CIRCULATIONAHA.108.824151.
– reference: Boyd CM, Xue QL, Simpson CF, et al. Frailty, hospitalization, and progression of disability in a cohort of disabled older women. Am J Med 2005; 118(11): 1225-31. doi:10.1016/j.amjmed.2005.01.062.
– reference: Searle SD, Mitnitski A, Gahbauer EA, et al. A standard procedure for creating a frailty index. BMC Geriatr 2008; 8: 24. doi:10.1186/1471-2318-8-24.
– reference: Nichol KL, Nordin JD, Nelson DB, et al. Effectiveness of influenza vaccine in the community-dwelling elderly. N Engl J Med 2007; 357(14): 1373-81. doi:10.1056/NEJMoa070844.
– reference: Ensrud KE, Ewing SK, Taylor BC, et al. Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. Arch Intern Med 2008; 168(4): 382-9. doi:10.1001/archinternmed.2007.113.
– reference: Rockwood K, Hogan DB, MacKnight C. Conceptualisation and measurement of frailty in elderly people. Drugs Aging 2000; 17(4): 295-302.
– reference: Jackson LA, Nelson JC, Benson P, et al. Functional status is a confounder of influenza vaccine and risk of all cause mortality in seniors. Int J Epidemiol 2006; 35(2): 345-352. doi:10.1093/ije/dyi274.
– reference: Walter LC, Brand RJ, Counsell SR, et al. Development and validation of a prognostic index for 1-year mortality in older adults after hospitalization. JAMA 2001; 285(23): 2987-94.
– reference: Noyes K, Liu H, Holloway R, et al. Accuracy of Medicare claims data in identifying Parkinsonism cases: comparison with the Medicare current beneficiary survey. Movement disorders : official journal of the Movement Disorder Society 2007; 22(4): 509-14. doi:10.1002/mds.21299.
– reference: Jackson ML, Yu O, Nelson JC, et al. Further evidence for bias in observational studies of influenza vaccine effectiveness: the 2009 influenza A(H1N1) pandemic. Am J Epidemiol 2013; 178(8): 1327-36. doi:10.1093/aje/kwt124.
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SubjectTerms epidemiologic methods
frailty
functional limitation
pharmacoepidemiology
unmeasured confounding
Title Using claims data to predict dependency in activities of daily living as a proxy for frailty
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