Women with polycystic ovary syndrome have elevated serum concentrations of and altered GABAA receptor sensitivity to allopregnanolone

Summary Objective Several studies have reported that γ‐aminobutyric acid (GABA) ergic circuits are involved in the pathophysiology of polycystic ovary syndrome (PCOS). The progesterone metabolite allopregnanolone is a potent GABAA‐receptor‐modulating steroid, and patients may have increased concentr...

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Bibliographic Details

Published in:	Clinical endocrinology (Oxford) Vol. 83; no. 5; pp. 643 - 650
Main Authors:	Hedström, Helena, Bäckström, Torbjörn, Bixo, Marie, Nyberg, Sigrid, Wang, Mingde, Gideonsson, Ida, Turkmen, Sahruh
Format:	Journal Article
Language:	English
Published:	Oxford Blackwell Publishing Ltd 01.11.2015 Wiley Subscription Services, Inc
ISSN:	0300-0664, 1365-2265
Online Access:	Get full text
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