Enhanced levels of prostaglandin E2 and matrix metalloproteinase-2 correlate with the severity of airflow limitation in stable COPD

Background and objective: Cyclooxygenase‐2 (COX‐2) and its product prostaglandin E2 (PGE2) have been demonstrated to play critical roles in inflammation in respiratory diseases. However, the role of COX‐2 in airway remodelling in COPD remains to be elucidated. Matrix metalloproteinase‐2 (MMP‐2) is...

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Bibliographic Details
Published in:	Respirology (Carlton, Vic.) Vol. 13; no. 7; pp. 1014 - 1021
Main Authors:	CHEN, Yan, CHEN, Ping, HANAOKA, Masayuki, DROMA, Yunden, KUBO, Keishi
Format:	Journal Article
Language:	English
Published:	Melbourne, Australia Blackwell Publishing Asia 01.11.2008
Subjects:	airflow limitation airway remodelling Airway Resistance - physiology Asthma - diagnosis Asthma - metabolism Asthma - physiopathology Blotting, Western COPD Cyclooxygenase 2 - biosynthesis cyclooxygenase-2 Dinoprostone - biosynthesis Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Forced Expiratory Volume - physiology Humans Male Matrix Metalloproteinase 2 - biosynthesis matrix metalloproteinase-2 Middle Aged prostaglandin E2 Severity of Illness Index Sputum - chemistry Time Factors
ISSN:	1323-7799, 1440-1843, 1440-1843
Online Access:	Get full text
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