Label-free Identification of Nonelectrogenic Cancer Cells using Adhesion Noise

Time-continuous detection of cells on substrates without the need of optical microscopic imaging is of broad interest in biotechnological applications. We present a method how to detect cancer cells using voltage noise caused by cell adhesion which is recorded by high-density CMOS-based microelectro...

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Bibliographic Details
Published in:2023 IEEE BioSensors Conference (BioSensors) pp. 1 - 4
Main Authors: Ell, Maximilian, Zeitler, Ralf, Thewes, Roland, Zeck, Gunther
Format: Conference Proceeding
Language:English
Published: IEEE 30.07.2023
Subjects:
Adhesives
Arrays
Biosensors
cell adhesion noise
CMOS-based microelectrode array
HT-29 cell
Microelectrodes
Optical recording
Power system measurements
Voltage
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Summary:Time-continuous detection of cells on substrates without the need of optical microscopic imaging is of broad interest in biotechnological applications. We present a method how to detect cancer cells using voltage noise caused by cell adhesion which is recorded by high-density CMOS-based microelectrode arrays. We analyze our data in terms of spectral power density for two different types of arrays, each of them being optimized in a different working regime.
DOI:10.1109/BioSensors58001.2023.10280952