Partial inhibition of Cdk1 in G2 phase overrides the SAC and decouples mitotic events

Entry and progression through mitosis has traditionally been linked directly to the activity of cyclin-dependent kinase 1 (Cdk1). In this study we utilized low doses of the Cdk1-specific inhibitor, RO3306 from early G 2 phase onwards. Addition of low doses of RO3306 in G 2 phase induced minor chromo...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 13; no. 9; pp. 1400 - 1412
Main Authors:	McCloy, Rachael A, Rogers, Samuel, Caldon, C Elizabeth, Lorca, Thierry, Castro, Anna, Burgess, Andrew
Format:	Journal Article
Language:	English
Published:	Taylor & Francis 01.05.2014 Landes Bioscience
Subjects:	Cdk1 cyclin B1 mitosis PP2A RO3306 SAC
ISSN:	1538-4101, 1551-4005
Online Access:	Get full text
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