Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate

To evaluate peripheral blood expression of genes regulated by nuclear factor-kappaB (NF-kappaB), a key mediator of tumor necrosis factor-alpha (TNF-alpha) signaling, in patients with rheumatoid arthritis (RA) before and during treatment with anti-TNF-alpha or methotrexate (MTX). We analyzed associat...

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Veröffentlicht in:	Journal of rheumatology Jg. 34; H. 9; S. 1817
Hauptverfasser:	Parker, Alex, Izmailova, Elena S, Narang, Jigna, Badola, Sunita, Le, Tinh, Roubenoff, Ronenn, Ginsburg, Geoffrey S, Maier, Agnes, Coblyn, Jonathan S, Shadick, Nancy A, Weinblatt, Michael E
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Canada 01.09.2007
Schlagworte:	Adult Aged Antirheumatic Agents - pharmacology Arthritis, Rheumatoid - drug therapy Biomarkers Down-Regulation - drug effects Female Gene Expression Regulation - drug effects Humans Male Methotrexate - pharmacology Middle Aged NF-kappa B p50 Subunit - drug effects Receptors, Tumor Necrosis Factor - administration & dosage Severity of Illness Index Tumor Necrosis Factor-alpha - antagonists & inhibitors Up-Regulation - drug effects
ISSN:	0315-162X
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