Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigenK164R mutant mice

Proliferating cell nuclear antigen (PCNA) encircles DNA as a ring-shaped homotrimer and, by tethering DNA polymerases to their template, PCNA serves as a critical replication factor. In contrast to high-fidelity DNA polymerases, the activation of low-fidelity translesion synthesis (TLS) DNA polymera...

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Veröffentlicht in:	Philosophical transactions of the Royal Society of London. Series B. Biological sciences Jg. 364; H. 1517; S. 621
Hauptverfasser:	Langerak, Petra, Krijger, Peter H L, Heideman, Marinus R, van den Berk, Paul C M, Jacobs, Heinz
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 12.03.2009
Schlagworte:	Animals DNA Mutational Analysis DNA Repair DNA-Directed DNA Polymerase - metabolism Mice Mice, Mutant Strains Models, Genetic Nucleotidyltransferases - metabolism Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism Somatic Hypermutation, Immunoglobulin - genetics Ubiquitination
ISSN:	1471-2970, 1471-2970
Online-Zugang:	Weitere Angaben
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