Consensus statement: Virus taxonomy in the age of metagenomics

The number and diversity of viral sequences that are identified in metagenomic data far exceeds that of experimentally characterized virus isolates. In a recent workshop, a panel of experts discussed the proposal that, with appropriate quality control, viruses that are known only from metagenomic da...

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Published in:Nature reviews. Microbiology Vol. 15; no. 3; pp. 161 - 168
Main Authors: Simmonds, Peter, Adams, Mike J, Benkő, Mária, Breitbart, Mya, Brister, J Rodney, Carstens, Eric B, Davison, Andrew J, Delwart, Eric, Gorbalenya, Alexander E, Harrach, Balázs, Hull, Roger, King, Andrew M Q, Koonin, Eugene V, Krupovic, Mart, Kuhn, Jens H, Lefkowitz, Elliot J, Nibert, Max L, Orton, Richard, Roossinck, Marilyn J, Sabanadzovic, Sead, Sullivan, Matthew B, Suttle, Curtis A, Tesh, Robert B, van der Vlugt, René A, Varsani, Arvind, Zerbini, F Murilo
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.03.2017
Subjects:
Base Sequence
Base Sequence - genetics
Biodiversity
Biointeractions and Plant Health
Genomes
High-Throughput Nucleotide Sequencing
Laboratorium voor Virologie
Laboratory of Virology
Life Sciences
Metagenomics
Microbiology and Parasitology
PE&RC
PPO/PRI Biointeracties en plantgezondheid
PPO/PRI Biointeractions and Plant Health
Quality control
Systematics, Phylogenetics and taxonomy
Taxonomy
Virology
Viruses
Viruses - classification
Viruses - genetics
United Kingdom > UK
ISSN:1740-1526, 1740-1534, 1740-1534
Online Access:Get full text
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Summary:The number and diversity of viral sequences that are identified in metagenomic data far exceeds that of experimentally characterized virus isolates. In a recent workshop, a panel of experts discussed the proposal that, with appropriate quality control, viruses that are known only from metagenomic data can, and should be, incorporated into the official classification scheme of the International Committee on Taxonomy of Viruses (ICTV). Although a taxonomy that is based on metagenomic sequence data alone represents a substantial departure from the traditional reliance on phenotypic properties, the development of a robust framework for sequence-based virus taxonomy is indispensable for the comprehensive characterization of the global virome. In this Consensus Statement article, we consider the rationale for why metagenomic sequence data should, and how it can, be incorporated into the ICTV taxonomy, and present proposals that have been endorsed by the Executive Committee of the ICTV.
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ISSN:1740-1526
1740-1534
1740-1534
DOI:10.1038/nrmicro.2016.177