BBR 3464: a novel triplatinum complex, exhibiting a preclinical profile of antitumor efficacy different from cisplatin

Multinuclear platinum complexes represent a new class of anticancer agents, distinct in terms of DNA binding features and the profile of antitumor activity from their mononuclear counterparts, in particular cisplatin. Among complexes of this class, BBR 3464, a trinuclear platinum compound has been s...

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Veröffentlicht in:	Clinical cancer research Jg. 6; H. 7; S. 2626
Hauptverfasser:	Manzotti, C, Pratesi, G, Menta, E, Di Domenico, R, Cavalletti, E, Fiebig, H H, Kelland, L R, Farrell, N, Polizzi, D, Supino, R, Pezzoni, G, Zunino, F
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.07.2000
Schlagworte:	Animals Antineoplastic Agents - toxicity Carcinoma, Small Cell - drug therapy Carcinoma, Small Cell - pathology Cell Cycle - drug effects Cell Survival - drug effects Cisplatin - toxicity Drug Screening Assays, Antitumor Female Humans Lung Neoplasms - drug therapy Lung Neoplasms - pathology Melanoma Mice Mice, Nude Organoplatinum Compounds - toxicity Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology Stomach Neoplasms - drug therapy Stomach Neoplasms - pathology Tumor Cells, Cultured Xenograft Model Antitumor Assays
ISSN:	1078-0432
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