EAACI guideline: Anaphylaxis (2021 update)

Anaphylaxis is a clinical emergency which all healthcare professionals need to be able to recognize and manage. The European Academy of Allergy and Clinical Immunology Anaphylaxis multidisciplinary Task Force has updated the 2014 guideline. The guideline was developed using the AGREE II framework an...

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Vydané v:Allergy (Copenhagen) Ročník 77; číslo 2; s. 357 - 377
Hlavní autori: Muraro, Antonella, Worm, Margitta, Alviani, Cherry, Cardona, Victoria, Dunngalvin, Audrey, Garvey, Lene Heise, Riggioni, Carmen, de Silva, Debra, Angier, Elizabeth, Arasi, Stefania, Bellou, Abdelouahab, Beyer, Kirsten, Bijlhout, Diola, Bilò, Maria Beatrice, Bindslev-Jensen, Carsten, Brockow, Knut, Fernandez-Rivas, Montserrat, Halken, Susanne, Jensen, Britt, Khaleva, Ekaterina, Michaelis, Louise J, Oude Elberink, Hanneke N G, Regent, Lynne, Sanchez, Angel, Vlieg-Boerstra, Berber J, Roberts, Graham
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Wiley 01.02.2022
Predmet:
Life Sciences
guidelines
anaphylaxis
children
adults
ISSN:0105-4538, 1398-9995
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Abstract Anaphylaxis is a clinical emergency which all healthcare professionals need to be able to recognize and manage. The European Academy of Allergy and Clinical Immunology Anaphylaxis multidisciplinary Task Force has updated the 2014 guideline. The guideline was developed using the AGREE II framework and the GRADE approach. The evidence was systematically reviewed and recommendations were created by weighing up benefits and harms. The guideline was peer-reviewed by external experts and reviewed in a public consultation. The use of clinical criteria to identify anaphylaxis is suggested with blood sampling for the later measurement of tryptase. The prompt use of intramuscular adrenaline as first-line management is recommended with the availability of adrenaline autoinjectors to patients in the community. Pharmacokinetic data should be provided for adrenaline autoinjector devices. Structured, comprehensive training for people at risk of anaphylaxis is recommended. Simulation training and visual prompts for healthcare professionals are suggested to improve the management of anaphylaxis. It is suggested that school policies reflect anaphylaxis guidelines. The evidence for the management of anaphylaxis remains mostly at a very low level. There is an urgent need to prioritize clinical trials with the potential to improve the management of patients at risk of anaphylaxis.
AbstractList Anaphylaxis is a clinical emergency which all healthcare professionals need to be able to recognize and manage. The European Academy of Allergy and Clinical Immunology Anaphylaxis multidisciplinary Task Force has updated the 2014 guideline. The guideline was developed using the AGREE II framework and the GRADE approach. The evidence was systematically reviewed and recommendations were created by weighing up benefits and harms. The guideline was peer-reviewed by external experts and reviewed in a public consultation. The use of clinical criteria to identify anaphylaxis is suggested with blood sampling for the later measurement of tryptase. The prompt use of intramuscular adrenaline as first-line management is recommended with the availability of adrenaline autoinjectors to patients in the community. Pharmacokinetic data should be provided for adrenaline autoinjector devices. Structured, comprehensive training for people at risk of anaphylaxis is recommended. Simulation training and visual prompts for healthcare professionals are suggested to improve the management of anaphylaxis. It is suggested that school policies reflect anaphylaxis guidelines. The evidence for the management of anaphylaxis remains mostly at a very low level. There is an urgent need to prioritize clinical trials with the potential to improve the management of patients at risk of anaphylaxis.
Author Riggioni, Carmen
Arasi, Stefania
Alviani, Cherry
Cardona, Victoria
Halken, Susanne
Roberts, Graham
Oude Elberink, Hanneke N G
Garvey, Lene Heise
Vlieg-Boerstra, Berber J
Beyer, Kirsten
Khaleva, Ekaterina
Michaelis, Louise J
Bijlhout, Diola
Brockow, Knut
Worm, Margitta
Regent, Lynne
Jensen, Britt
Muraro, Antonella
Dunngalvin, Audrey
Bellou, Abdelouahab
de Silva, Debra
Fernandez-Rivas, Montserrat
Bilò, Maria Beatrice
Angier, Elizabeth
Bindslev-Jensen, Carsten
Sanchez, Angel
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  organization: University of Southampton
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  organization: Istituti di Ricovero e Cura a Carattere Scientifico
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  givenname: Abdelouahab
  orcidid: 0000-0003-3457-5585
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  fullname: Bellou, Abdelouahab
  organization: Wayne State University School of Medicine
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  organization: Technische Universität Munchen - Technical University Munich - Université Technique de Munich
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  organization: Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain]
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  organization: OLVG Hospital
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  surname: Roberts
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  organization: University of Southampton
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