Liquid Chromatography-Tandem Mass Spectrometry-Based [alpha]1-Antitrypsin Testing: A Retrospective Evaluation of a Clinical Algorithm to Detect AAT Deficiency

Objectives: Failure to produce sufficient quantities of functional [alpha]1-antitrypsin (AAT) can result in AAT deficiency (AATD) and significant comorbidities. Laboratory testing plays a vital role in AATD, with diagnosis requiring documentation of both a low AAT level and a mutated allele. This re...

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Bibliographic Details
Published in:	American journal of clinical pathology Vol. 155; no. 4; p. 547
Main Authors:	Murray, Josiah D, Willrich, Maria A, Krowka, Michael J, Bobr, Aleh, Murray, David L, Halling, Kevin C, Graham, Rondell P, Snyder, Melissa R
Format:	Journal Article
Language:	English
Published:	Oxford University Press 01.04.2021
Subjects:	Algorithms Alpha 1-antitrypsin Comorbidity Gene mutations Information management Liquid chromatography Mass spectrometry
ISSN:	0002-9173
Online Access:	Get full text
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