Blockade of senescence‐associated microRNA‐195 in aged skeletal muscle cells facilitates reprogramming to produce induced pluripotent stem cells

Summary The low reprogramming efficiency in cells from elderly patients is a challenge that must be overcome. Recently, it has been reported that senescence‐associated microRNA (miR)‐195 targets Sirtuin 1 (SIRT1) to advance cellular senescence. Thus, we hypothesized that a blockade of miR‐195 expres...

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Bibliographic Details
Published in:	Aging cell Vol. 15; no. 1; pp. 56 - 66
Main Authors:	Kondo, Hideyuki, Kim, Ha Won, Wang, Lei, Okada, Motoi, Paul, Christian, Millard, Ronald W., Wang, Yigang
Format:	Journal Article
Language:	English
Published:	England John Wiley & Sons, Inc 01.02.2016 John Wiley and Sons Inc
Subjects:	Age Factors aging cell Animals Cell Differentiation - physiology Cells, Cultured Cellular Reprogramming - genetics Cellular Senescence Comparative analysis Fibroblasts - cytology Induced Pluripotent Stem Cells - metabolism Mice Mice, Inbred C57BL MicroRNA MicroRNAs - metabolism Muscle Fibers, Skeletal - cytology Muscle Fibers, Skeletal - metabolism Muscles Original reprogramming Stem cells Telomerase telomere length Telomeres reprogramming microRNA aging cell telomere length
ISSN:	1474-9718, 1474-9726, 1474-9726
Online Access:	Get full text
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