The biogenesis, biology and characterization of circular RNAs

Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules in eukaryotes with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by specific cis-acting elements and trans-acting factors. Some circRNAs are abundant and evolutionarily conserved, and many...

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Vydáno v:	Nature reviews. Genetics Ročník 20; číslo 11; s. 675 - 691
Hlavní autoři:	Kristensen, Lasse S, Andersen, Maria S, Stagsted, Lotte V W, Ebbesen, Karoline K, Hansen, Thomas B, Kjems, Jørgen
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Nature Publishing Group 01.11.2019
Témata:	Biosynthesis Cardiovascular diseases Cardiovascular Diseases - genetics Cardiovascular Diseases - metabolism Computational neuroscience Diabetes mellitus Diabetes Mellitus - genetics Diabetes Mellitus - metabolism Humans MicroRNAs - biosynthesis MicroRNAs - genetics miRNA Neoplasms - genetics Neoplasms - metabolism Nervous System Diseases - genetics Nervous System Diseases - metabolism Neurological diseases RNA, Circular - biosynthesis RNA, Circular - genetics RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics
ISSN:	1471-0056, 1471-0064, 1471-0064
On-line přístup:	Získat plný text
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Shrnutí:	Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules in eukaryotes with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by specific cis-acting elements and trans-acting factors. Some circRNAs are abundant and evolutionarily conserved, and many circRNAs exert important biological functions by acting as microRNA or protein inhibitors ('sponges'), by regulating protein function or by being translated themselves. Furthermore, circRNAs have been implicated in diseases such as diabetes mellitus, neurological disorders, cardiovascular diseases and cancer. Although the circular nature of these transcripts makes their detection, quantification and functional characterization challenging, recent advances in high-throughput RNA sequencing and circRNA-specific computational tools have driven the development of state-of-the-art approaches for their identification, and novel approaches to functional characterization are emerging.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Literature Review-3 ObjectType-Review-3 content type line 23
ISSN:	1471-0056 1471-0064 1471-0064
DOI:	10.1038/s41576-019-0158-7