The Klotho proteins in health and disease

The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity binding of FGF19, FGF21 and FGF23 to their cognate FGF receptors (FGFRs). Collectively, these proteins form a unique endocrine...

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Bibliographic Details
Published in:	Nature reviews. Nephrology Vol. 15; no. 1; pp. 27 - 44
Main Author:	Kuro-O, Makoto
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.01.2019
Subjects:	Aging - physiology Animals Biomarkers - metabolism Birds Cardiovascular Diseases - metabolism Cardiovascular Diseases - physiopathology Cardiovascular Diseases - therapy Endocrine system Endocrine System Diseases - metabolism Endocrine System Diseases - physiopathology Endocrine System Diseases - therapy Fibroblast Growth Factor-23 Fibroblast Growth Factors - metabolism Fibroblasts Glucuronidase - chemistry Glucuronidase - physiology Growth factors Humans Hypothalamo-Hypophyseal System - physiology Hypothalamo-Hypophyseal System - physiopathology Kidney diseases Kidney Diseases - metabolism Kidney Diseases - physiopathology Kidney Diseases - therapy Klotho Proteins Mammals Metabolism Nervous system Phosphates - metabolism Pituitary-Adrenal System - physiology Pituitary-Adrenal System - physiopathology Proteins
ISSN:	1759-5061, 1759-507X, 1759-507X
Online Access:	Get full text
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