Can Ultrasound of the Tibial Nerve Detect Diabetic Peripheral Neuropathy?: A cross-sectional study

Peripheral nerve imaging by portable ultrasound (US) may serve as a noninvasive and lower-cost alternative to nerve conduction studies (NCS) for diagnosis and staging of diabetic sensorimotor polyneuropathy (DSP). We aimed to examine the association between the size of the posterior tibial nerve (PT...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Diabetes care Ročník 35; číslo 12; s. 2575 - 2579
Hlavní autori:	RIAZI, Sheila, BRIL, Vera, PERKINS, Bruce A, ABBAS, Sherif, CHAN, Vincent W. S, NGO, Mylan, LOVBLOM, Leif E, EL-BEHEIRY, Hossam, BRULL, Richard
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Alexandria, VA American Diabetes Association 01.12.2012
Predmet:	Age Aged Biological and medical sciences Blood pressure Cross-Sectional Studies Diabetes Diabetes. Impaired glucose tolerance Diabetic Neuropathies - diagnosis Diabetic Neuropathies - diagnostic imaging Diabetic neuropathy Digital signal processors Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Hospitals Humans Male Medical sciences Metabolic diseases Middle Aged Miscellaneous Original Research Public health. Hygiene Public health. Hygiene-occupational medicine Regression analysis Studies Tibial Nerve - diagnostic imaging Tibial Nerve - pathology Ultrasonic imaging Ultrasonography Variables Ontario United States > US Endocrinopathy Sonography Human Nervous system diseases Tibial nerve Nutrition Diabetes mellitus Cross sectional study Metabolic diseases Peripheral nerve disease Ultrasound Endocrinology
ISSN:	0149-5992, 1935-5548, 1935-5548
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Popis
Shrnutí:	Peripheral nerve imaging by portable ultrasound (US) may serve as a noninvasive and lower-cost alternative to nerve conduction studies (NCS) for diagnosis and staging of diabetic sensorimotor polyneuropathy (DSP). We aimed to examine the association between the size of the posterior tibial nerve (PTN) and the presence and severity of DSP. We performed a cross-sectional study of 98 consecutive diabetic patients classified by NCS as subjects with DSP or control subjects. Severity was determined using the Toronto Clinical Neuropathy Score. A masked expert sonographer measured the cross-sectional area (CSA) of the PTN at 1, 3, and 5 cm proximal to the medial malleolus. Fifty-five patients had DSP. The mean CSA of the PTN in DSP compared with control subjects at distances of 1 (23.03 vs. 17.72 mm(2); P = 0.004), 3 (22.59 vs. 17.69 mm(2); P < 0.0001), and 5 cm (22.05 vs. 17.25 mm(2); P = 0.0005) proximal to the medial malleolus was significantly larger. Although the area under the curve (AUC) for CSA measurements at all three anatomical levels was similar, the CSA measured at 3 cm above the medial malleolus had an optimal threshold value for identification of DSP (19.01 mm(2)) with a sensitivity of 0.69 and a specificity of 0.77 by AUC analysis. This large study of diabetic patients confirms that the CSA of the PTN is larger in patients with DSP than in control subjects, and US is a promising point-of-care screening tool for DSP.
Bibliografia:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23
ISSN:	0149-5992 1935-5548 1935-5548
DOI:	10.2337/dc12-0739