Dynamic Architecture of Eukaryotic DNA Replication Forks In Vivo, Visualized by Electron Microscopy

The DNA replication process can be heavily perturbed by several different conditions of genotoxic stress, particularly relevant for cancer onset and therapy. The combination of psoralen crosslinking and electron microscopy has proven instrumental to reveal the fine architecture of in vivo DNA replic...

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Vydané v:	Methods in molecular biology (Clifton, N.J.) Ročník 1672; s. 261
Hlavní autori:	Zellweger, Ralph, Lopes, Massimo
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.01.2018
Predmet:	Animals Cross-Linking Reagents DNA Replication DNA, Fungal - ultrastructure DNA, Single-Stranded - ultrastructure Eukaryotic Cells - physiology Microscopy, Electron Nucleosomes - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism DNA replication Nucleosome position Replication fork reversal In vivo replication intermediates Electron microscopy ssDNA Psoralen crosslinking
ISSN:	1940-6029, 1940-6029
On-line prístup:	Zistit podrobnosti o prístupe
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