Dynamic Architecture of Eukaryotic DNA Replication Forks In Vivo, Visualized by Electron Microscopy

The DNA replication process can be heavily perturbed by several different conditions of genotoxic stress, particularly relevant for cancer onset and therapy. The combination of psoralen crosslinking and electron microscopy has proven instrumental to reveal the fine architecture of in vivo DNA replic...

Full description

Saved in:

Bibliographic Details
Published in:	Methods in molecular biology (Clifton, N.J.) Vol. 1672; p. 261
Main Authors:	Zellweger, Ralph, Lopes, Massimo
Format:	Journal Article
Language:	English
Published:	United States 01.01.2018
Subjects:	Animals Cross-Linking Reagents DNA Replication DNA, Fungal - ultrastructure DNA, Single-Stranded - ultrastructure Eukaryotic Cells - physiology Microscopy, Electron Nucleosomes - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism DNA replication Nucleosome position Replication fork reversal In vivo replication intermediates Electron microscopy ssDNA Psoralen crosslinking
ISSN:	1940-6029, 1940-6029
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!