Mechanisms of Oxidative Stress in Metabolic Syndrome

Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to obesity. Increased adiposity promotes inflammation and oxidative stress, which are precursors of various complications invol...

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Veröffentlicht in:International journal of molecular sciences Jg. 24; H. 9; S. 7898
Hauptverfasser: Masenga, Sepiso K, Kabwe, Lombe S, Chakulya, Martin, Kirabo, Annet
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 26.04.2023
MDPI
Schlagworte:
Abdomen
Antioxidants
Apoptosis
B cells
Blood pressure
Cardiovascular disease
Cholesterol
Development and progression
Diabetes Mellitus, Type 2 - metabolism
Enzymes
Glucose
Humans
Hyperglycemia
Hypertension
Inflammation
Inflammation - complications
Insulin Resistance
Kinases
Lipids
Lipoproteins
Medical research
Medicine, Experimental
Metabolic disorders
Metabolic syndrome
Metabolic Syndrome - metabolism
Mitochondria
Obesity
Obesity - metabolism
Oxidative Stress
Plasma
Proteins
Reactive oxygen species
Review
Risk factors
Thromboembolism
Transcription factors
Triglycerides
Type 2 diabetes
Canada
metabolic syndrome
cardiovascular disease
hyperglycemia
hyperlipidemia
inflammatory cytokines
hypertension
insulin resistance
obesity
oxidative stress
ISSN:1422-0067, 1661-6596, 1422-0067
Online-Zugang:Volltext
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Zusammenfassung:Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to obesity. Increased adiposity promotes inflammation and oxidative stress, which are precursors of various complications involving metabolic syndrome components, namely insulin resistance, hypertension, and hyperlipidemia. An increasing number of studies confirm the importance of oxidative stress and chronic inflammation in the etiology of metabolic syndrome. However, few studies have reviewed the mechanisms underlying the role of oxidative stress in contributing to metabolic syndrome. In this review, we highlight mechanisms by which reactive oxygen species (ROS) increase mitochondrial dysfunction, protein damage, lipid peroxidation, and impair antioxidant function in metabolic syndrome. Biomarkers of oxidative stress can be used in disease diagnosis and evaluation of severity.
Bibliographie:ObjectType-Article-1
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ObjectType-Feature-2
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24097898