Mechanisms of Oxidative Stress in Metabolic Syndrome

Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to obesity. Increased adiposity promotes inflammation and oxidative stress, which are precursors of various complications invol...

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Vydáno v:	International journal of molecular sciences Ročník 24; číslo 9; s. 7898
Hlavní autoři:	Masenga, Sepiso K, Kabwe, Lombe S, Chakulya, Martin, Kirabo, Annet
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland MDPI AG 26.04.2023 MDPI
Témata:	Abdomen Antioxidants Apoptosis B cells Blood pressure Cardiovascular disease Cholesterol Development and progression Diabetes Mellitus, Type 2 - metabolism Enzymes Glucose Humans Hyperglycemia Hypertension Inflammation Inflammation - complications Insulin Resistance Kinases Lipids Lipoproteins Medical research Medicine, Experimental Metabolic disorders Metabolic syndrome Metabolic Syndrome - metabolism Mitochondria Obesity Obesity - metabolism Oxidative Stress Plasma Proteins Reactive oxygen species Review Risk factors Thromboembolism Transcription factors Triglycerides Type 2 diabetes Canada metabolic syndrome cardiovascular disease hyperglycemia hyperlipidemia inflammatory cytokines hypertension insulin resistance obesity oxidative stress
ISSN:	1422-0067, 1661-6596, 1422-0067
On-line přístup:	Získat plný text
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Popis
Shrnutí:	Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to obesity. Increased adiposity promotes inflammation and oxidative stress, which are precursors of various complications involving metabolic syndrome components, namely insulin resistance, hypertension, and hyperlipidemia. An increasing number of studies confirm the importance of oxidative stress and chronic inflammation in the etiology of metabolic syndrome. However, few studies have reviewed the mechanisms underlying the role of oxidative stress in contributing to metabolic syndrome. In this review, we highlight mechanisms by which reactive oxygen species (ROS) increase mitochondrial dysfunction, protein damage, lipid peroxidation, and impair antioxidant function in metabolic syndrome. Biomarkers of oxidative stress can be used in disease diagnosis and evaluation of severity.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms24097898