Mechanisms of Oxidative Stress in Metabolic Syndrome
Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to obesity. Increased adiposity promotes inflammation and oxidative stress, which are precursors of various complications invol...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences Jg. 24; H. 9; S. 7898 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Switzerland
MDPI AG
26.04.2023
MDPI |
| Schlagworte: | |
| ISSN: | 1422-0067, 1661-6596, 1422-0067 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to obesity. Increased adiposity promotes inflammation and oxidative stress, which are precursors of various complications involving metabolic syndrome components, namely insulin resistance, hypertension, and hyperlipidemia. An increasing number of studies confirm the importance of oxidative stress and chronic inflammation in the etiology of metabolic syndrome. However, few studies have reviewed the mechanisms underlying the role of oxidative stress in contributing to metabolic syndrome. In this review, we highlight mechanisms by which reactive oxygen species (ROS) increase mitochondrial dysfunction, protein damage, lipid peroxidation, and impair antioxidant function in metabolic syndrome. Biomarkers of oxidative stress can be used in disease diagnosis and evaluation of severity. |
|---|---|
| AbstractList | Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to obesity. Increased adiposity promotes inflammation and oxidative stress, which are precursors of various complications involving metabolic syndrome components, namely insulin resistance, hypertension, and hyperlipidemia. An increasing number of studies confirm the importance of oxidative stress and chronic inflammation in the etiology of metabolic syndrome. However, few studies have reviewed the mechanisms underlying the role of oxidative stress in contributing to metabolic syndrome. In this review, we highlight mechanisms by which reactive oxygen species (ROS) increase mitochondrial dysfunction, protein damage, lipid peroxidation, and impair antioxidant function in metabolic syndrome. Biomarkers of oxidative stress can be used in disease diagnosis and evaluation of severity. Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to obesity. Increased adiposity promotes inflammation and oxidative stress, which are precursors of various complications involving metabolic syndrome components, namely insulin resistance, hypertension, and hyperlipidemia. An increasing number of studies confirm the importance of oxidative stress and chronic inflammation in the etiology of metabolic syndrome. However, few studies have reviewed the mechanisms underlying the role of oxidative stress in contributing to metabolic syndrome. In this review, we highlight mechanisms by which reactive oxygen species (ROS) increase mitochondrial dysfunction, protein damage, lipid peroxidation, and impair antioxidant function in metabolic syndrome. Biomarkers of oxidative stress can be used in disease diagnosis and evaluation of severity.Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to obesity. Increased adiposity promotes inflammation and oxidative stress, which are precursors of various complications involving metabolic syndrome components, namely insulin resistance, hypertension, and hyperlipidemia. An increasing number of studies confirm the importance of oxidative stress and chronic inflammation in the etiology of metabolic syndrome. However, few studies have reviewed the mechanisms underlying the role of oxidative stress in contributing to metabolic syndrome. In this review, we highlight mechanisms by which reactive oxygen species (ROS) increase mitochondrial dysfunction, protein damage, lipid peroxidation, and impair antioxidant function in metabolic syndrome. Biomarkers of oxidative stress can be used in disease diagnosis and evaluation of severity. |
| Audience | Academic |
| Author | Kabwe, Lombe S Masenga, Sepiso K Chakulya, Martin Kirabo, Annet |
| AuthorAffiliation | 2 Department of Medicine, Room 536 Robinson Research Building, Vanderbilt University Medical Centre, Nashville, TN 37232-6602, USA 1 HAND Research Group, School of Medicine and Health Sciences, Mulungushi University, Livingstone Campus, Livingstone P.O. Box 60009, Zambia |
| AuthorAffiliation_xml | – name: 1 HAND Research Group, School of Medicine and Health Sciences, Mulungushi University, Livingstone Campus, Livingstone P.O. Box 60009, Zambia – name: 2 Department of Medicine, Room 536 Robinson Research Building, Vanderbilt University Medical Centre, Nashville, TN 37232-6602, USA |
| Author_xml | – sequence: 1 givenname: Sepiso K orcidid: 0000-0003-4376-5831 surname: Masenga fullname: Masenga, Sepiso K organization: Department of Medicine, Room 536 Robinson Research Building, Vanderbilt University Medical Centre, Nashville, TN 37232-6602, USA – sequence: 2 givenname: Lombe S surname: Kabwe fullname: Kabwe, Lombe S organization: HAND Research Group, School of Medicine and Health Sciences, Mulungushi University, Livingstone Campus, Livingstone P.O. Box 60009, Zambia – sequence: 3 givenname: Martin surname: Chakulya fullname: Chakulya, Martin organization: HAND Research Group, School of Medicine and Health Sciences, Mulungushi University, Livingstone Campus, Livingstone P.O. Box 60009, Zambia – sequence: 4 givenname: Annet orcidid: 0000-0001-8580-9359 surname: Kirabo fullname: Kirabo, Annet organization: Department of Medicine, Room 536 Robinson Research Building, Vanderbilt University Medical Centre, Nashville, TN 37232-6602, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37175603$$D View this record in MEDLINE/PubMed |
| BookMark | eNptkctLxDAQxoMovm-epeDFy66TV9ucRBZfoHhQzyFtpmuWNtGmK-5_bxafK5LDhJnffMPHt0PWffBIyAGFMecKTtysi0yAKkpVrpFtKhgbAeTF-q__FtmJcQbAOJNqk2zxghYyB75NxC3WT8a72MUsNNndm7NmcK-Y3Q89xpg5n93iYKrQujq7X3jbhw73yEZj2oj7n3WXPF6cP0yuRjd3l9eTs5vRVAAMI2ZBWZMjMCvAFk1ZcWqZQimbSlLIc-QFVEogZwwEKwVCCQK4UMrIEhnfJacfus_zqkNbox960-rn3nWmX-hgnF6dePekp-FVU6BFSZVKCsefCn14mWMcdOdijW1rPIZ51KykXOZCcEjo0R90Fua9T_6WFJMScqA_1NS0qJ1vQjpcL0X1WSGZSEmIPFHjf6j0LHauTvk1LvVXFg5_O_22-BUUfwdAXJL- |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2023 MDPI AG 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2023 by the authors. 2023 |
| Copyright_xml | – notice: COPYRIGHT 2023 MDPI AG – notice: 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2023 by the authors. 2023 |
| DBID | CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88E 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH K9. M0S M1P M2O MBDVC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS Q9U 7X8 5PM |
| DOI | 10.3390/ijms24097898 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection (ProQuest) ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC ProQuest Central Database Suite (ProQuest) ProQuest One ProQuest Central Korea Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Medical Database ProQuest Research Library Research Library (Corporate) ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database Research Library Prep ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Research Library ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1422-0067 |
| ExternalDocumentID | PMC10178199 A752424046 37175603 |
| Genre | Journal Article Review |
| GeographicLocations | Canada |
| GeographicLocations_xml | – name: Canada |
| GrantInformation_xml | – fundername: NHLBI NIH HHS grantid: R01 HL147818 – fundername: FIC NIH HHS grantid: D43 TW009744 – fundername: FIC NIH HHS grantid: R03HL155041, R01HL147818, and R01HL144941 (AK) and 2D43TW009744 (SKM). – fundername: NHLBI NIH HHS grantid: R01 HL144941 – fundername: NHLBI NIH HHS grantid: R03 HL155041 – fundername: Fogarty International Center grantid: R03HL155041; R01HL147818; R01HL144941; 2D43TW009744 |
| GroupedDBID | --- 29J 2WC 3V. 53G 5GY 5VS 7X7 88E 8FE 8FG 8FH 8FI 8FJ 8G5 A8Z AADQD AAFWJ AAHBH ABDBF ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV AEAQA AENEX AFKRA AFZYC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI CCPQU CGR CS3 CUY CVF D1I DIK DU5 DWQXO E3Z EBD EBS ECM EIF EJD ESX F5P FRP FYUFA GNUQQ GROUPED_DOAJ GUQSH GX1 HCIFZ HH5 HMCUK HYE IAO IHR ITC KB. KQ8 LK8 M1P M2O M48 M7P MODMG M~E NPM O5R O5S OK1 P2P PDBOC PIMPY PQQKQ PROAC PSQYO RNS RPM TR2 TUS UKHRP ~8M AFFHD OVT PHGZM PHGZT PJZUB PPXIY ESTFP 7XB 8FK K9. MBDVC PKEHL PQEST PQUKI PRINS Q9U 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-g400t-2d09da6e02d40d7f8b31d29e55fb51066e370b94e32204284e080403499a58e23 |
| IEDL.DBID | BENPR |
| ISICitedReferencesCount | 361 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000987040300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1422-0067 1661-6596 |
| IngestDate | Tue Nov 04 02:07:23 EST 2025 Thu Oct 02 12:10:02 EDT 2025 Tue Oct 07 07:49:45 EDT 2025 Tue Nov 11 10:26:19 EST 2025 Sat Nov 29 09:54:34 EST 2025 Wed Feb 19 02:14:27 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Keywords | metabolic syndrome cardiovascular disease hyperglycemia hyperlipidemia inflammatory cytokines hypertension insulin resistance obesity oxidative stress |
| Language | English |
| License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-g400t-2d09da6e02d40d7f8b31d29e55fb51066e370b94e32204284e080403499a58e23 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ORCID | 0000-0003-4376-5831 0000-0001-8580-9359 |
| OpenAccessLink | https://www.proquest.com/docview/2812550601?pq-origsite=%requestingapplication% |
| PMID | 37175603 |
| PQID | 2812550601 |
| PQPubID | 2032341 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_10178199 proquest_miscellaneous_2813564430 proquest_journals_2812550601 gale_infotracmisc_A752424046 gale_infotracacademiconefile_A752424046 pubmed_primary_37175603 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-04-26 |
| PublicationDateYYYYMMDD | 2023-04-26 |
| PublicationDate_xml | – month: 04 year: 2023 text: 2023-04-26 day: 26 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland – name: Basel |
| PublicationTitle | International journal of molecular sciences |
| PublicationTitleAlternate | Int J Mol Sci |
| PublicationYear | 2023 |
| Publisher | MDPI AG MDPI |
| Publisher_xml | – name: MDPI AG – name: MDPI |
| SSID | ssj0023259 |
| Score | 2.7201583 |
| SecondaryResourceType | review_article |
| Snippet | Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is... |
| SourceID | pubmedcentral proquest gale pubmed |
| SourceType | Open Access Repository Aggregation Database Index Database |
| StartPage | 7898 |
| SubjectTerms | Abdomen Antioxidants Apoptosis B cells Blood pressure Cardiovascular disease Cholesterol Development and progression Diabetes Mellitus, Type 2 - metabolism Enzymes Glucose Humans Hyperglycemia Hypertension Inflammation Inflammation - complications Insulin Resistance Kinases Lipids Lipoproteins Medical research Medicine, Experimental Metabolic disorders Metabolic syndrome Metabolic Syndrome - metabolism Mitochondria Obesity Obesity - metabolism Oxidative Stress Plasma Proteins Reactive oxygen species Review Risk factors Thromboembolism Transcription factors Triglycerides Type 2 diabetes |
| Title | Mechanisms of Oxidative Stress in Metabolic Syndrome |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/37175603 https://www.proquest.com/docview/2812550601 https://www.proquest.com/docview/2813564430 https://pubmed.ncbi.nlm.nih.gov/PMC10178199 |
| Volume | 24 |
| WOSCitedRecordID | wos000987040300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1422-0067 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0023259 issn: 1422-0067 databaseCode: 7X7 dateStart: 20000301 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1422-0067 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0023259 issn: 1422-0067 databaseCode: BENPR dateStart: 20000301 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Research Library customDbUrl: eissn: 1422-0067 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0023259 issn: 1422-0067 databaseCode: M2O dateStart: 20000301 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1422-0067 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0023259 issn: 1422-0067 databaseCode: PIMPY dateStart: 20000301 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3dT9wwDLfgAImXwfjYOhgqEtKeKnpJ2iZPEyDQ9nDHaYB0PFVNmkLR6AE9EPz32G24UU3ay14qRXGiyrEdO3F-BthDnyCWBD6YFYIHQigdaCb7gdFS4_ZmmHbFJpLhUI7HauQO3GqXVvlmExtDnU8MnZHv4wTo_RJ6yPe7-4CqRtHtqiuhMQ8LhFQmerBweDwc_ZqFXJw15dL6uAsFcaTiNvWdY6C_X97c1ozQnqSSf9vjdxtSN1ny3e5zsvK__70KH5zf6R-0gvIR5my1BkttJcqXdRADS0-Ay_q29ieFf_pc5g0iuH_WvCXxy8of2CkKzO_S-GcO5WADLk6Oz49-BK6gQnCFqjoNWB6qPIttyHIR5kmBy9HPmbJRVGjUzTi2PAm1Eha1nGIpYdGfFIRgo7JIWsY3oVdNKvsZfG2YKozgOFEmlC2URoqI26yIdD_JEg--EUdTUhNkm8lctj-OJsCp9CCJ6GEKRucebHcoUbxNt_uNr6lTrzr9w1QPdmfdNJJSxio7eWxoeITeHg89-NQuYXrXInikHINYdPW4B7KzuDMCAt3u9lTldQO-TSYMvSj15d__tQXLVJie7p1YvA296cOj_QqL5mla1g87MJ-Mk-Yrd5zIYmvATrE1-jkYXb4CelT0SA |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1LT9wwEB4hoKIXoC3Q8GhdqainaLO28_ABIQRFINhtJai0tzR2HEhVskCW15_iNzKTZIEIqTcOPXtsWZl3PPMNwFeMCYKIwAeTTApXSqVdzaOua3Sk0b0ZrpthE2G_Hw0G6ucE3I97YaiscmwTK0OdDg39I-_gARj9EnrI5vmFS1Oj6HV1PEKjFosDe3eDKVu5sb-D_F3nfPf78fae20wVcE9QXkcuTz2VJoH1eCq9NMzwTt2UK-v7mUYBDQIrQk8raVHUKaGQFoMqSTAuKvEjS0AHaPKn0I6HVEIWDp4SPMGr4Wxd9Hlu4KugLrQXQnmd_M9ZyQlbKlLRS-v_zP21SzOf-brduf_tK83DbBNVs61aDd7BhC3ew5t6zubdB5A9Sw3OeXlWsmHGftzmaYV3zo6qThmWF6xnR6gOf3PDjhoMhwX49SpXXoTJYljYj8C04SozUuBBiVQ2UxopfGGTzNfdMAkd-EYcjMkIIJtM0vQy4G6C04q3Qp_abjwZOLDaokTlNe3lMR_jxniU8RMTHfjyuEw7qSCusMOrikb4GMsKz4GlWmTi8xqfJBaYomMgKxyIWsL0SECQ4u2VIj-toMXJQGOMqJb_fa_PMLN33DuMD_f7ByvwlqPo0wsbD1ZhcnR5Zddg2lyP8vLyU6UgDH6_tqw9ABh_R50 |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3dT9RAEJ8QQMILogJWUdYE4lNzvd3txz4YgsIFghwX0IS30t1uoYbrIT1U_jX-Omfa3klj4hsPPu_sZtP57s78BmATY4IgIvDBJJPClVJpV_Oo6xodaXRvhutm2ETY70dnZ2owA_eTXhgqq5zYxMpQpyND_8g7eABGv4Qe0smasojBbm_7-rtLE6TopXUyTqMWkUN79xPTt_LDwS7yeovz3t6XT_tuM2HAvUDZHbs89VSaBNbjqfTSMMP7dVOurO9nGoU1CKwIPa2kRbGn5EJaDLAkQbqoxI8sgR6g-Z8LMchA7Zr7uNcfnEzTPcGrUW1d9IBu4KugLrsXQnmd_Nuw5IQ0Fanob1_wwBm2CzUfeL7e0__5my3DUhNvs51aQZ7BjC2ew5N6AufdC5BHllqf83JYslHGjn_laYWEzk6rHhqWF-zIjlFRrnLDTht0hxX4-ihXXoXZYlTYl8C04SozUuBBiVQ2UxopfGGTzNfdMAkdeE_cjMk8IMtM0nQ54G4C2op3Qp8acjwZOLDeokS1Nu3lCU_jxqyU8R-GOvBuukw7qVSusKPbikb4GOUKz4G1Wnzi6xq5JBaYvGOIKxyIWoI1JSCw8fZKkV9WoONkujF6VK_-fa8NWEARiz8f9A9fwyJHLaCnNx6sw-z45ta-gXnzY5yXN28bbWFw_tjC9hsZLFG- |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mechanisms+of+Oxidative+Stress+in+Metabolic+Syndrome&rft.jtitle=International+journal+of+molecular+sciences&rft.au=Masenga%2C+Sepiso+K&rft.au=Kabwe%2C+Lombe+S&rft.au=Chakulya%2C+Martin&rft.au=Kirabo%2C+Annet&rft.date=2023-04-26&rft.issn=1422-0067&rft.eissn=1422-0067&rft.volume=24&rft.issue=9&rft_id=info:doi/10.3390%2Fijms24097898&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1422-0067&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1422-0067&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1422-0067&client=summon |