Building up PtII−Thiosemicarbazone−Lysine−sC18 Conjugates

Three chiral tridentate N^N^S coordinating pyridine‐carbaldehyde (S)‐N4‐(α‐methylbenzyl)thiosemicarbazones (HTSCmB) were synthesised along with lysine‐modified derivatives. One of them was selected and covalently conjugated to the cell‐penetrating peptide sC18 by solid‐phase peptide synthesis. The H...

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Vydané v:	Chembiochem : a European journal of chemical biology Ročník 22; číslo 4; s. 694 - 704
Hlavní autori:	Haseloer, Alexander, Lützenburg, Tamara, Strache, Joss Pepe, Neudörfl, Jörg, Neundorf, Ines, Klein, Axel
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	WEINHEIM Wiley 15.02.2021 Wiley Subscription Services, Inc John Wiley and Sons Inc
Predmet:	Antiproliferative Biochemistry & Molecular Biology Biological activity Cell lines Cell viability cell-penetrating peptides Chemistry, Medicinal Conjugates Coordination compounds Derivatives Infrared spectroscopy Labeling Life Sciences & Biomedicine Ligands Lysine NMR Nuclear magnetic resonance Nuclear medicine Peptide synthesis Peptides Pharmacology & Pharmacy platinum Pyridines Radioisotopes Science & Technology System effectiveness thiosemicarbazone Antiproliferative ANTIPROLIFERATIVE ACTIVITY PLATINUM(II) COMPLEXES CRYSTAL-STRUCTURE ANTITUMOR-ACTIVITY CYTOTOXIC ACTIVITY PEPTIDE PALLADIUM(II) COMPLEXES platinum conjugates cell-penetrating peptides BIS(THIOSEMICARBAZONE) COMPLEXES thiosemicarbazone BASIS-SETS
ISSN:	1439-4227, 1439-7633, 1439-7633
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