Bacteriophage Treatment of Infected Diabetic Foot Ulcers

Diabetic foot ulcers occur as a common complication of diabetes. Healing of the ulcers is largely delayed by the concomitant infection. Antibiotic treatment of infected ulcers is complicated by formation of microbial biofilms , which are often heterogeneous and resistant to antibiotics. Bacteriophag...

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Vydáno v:Methods in molecular biology (Clifton, N.J.) Ročník 1693; s. 151
Hlavní autoři: Morozova, Vera V, Kozlova, Yulia N, Ganichev, Denis A, Tikunova, Nina V
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 2018
Témata:
Bacterial Physiological Phenomena
Bacteriophages - physiology
Diabetic Foot - prevention & control
Humans
Middle Aged
Wound Healing
Wound Infection - microbiology
Wound Infection - prevention & control
Diabetes
Bacteriophage therapy
Diabetic foot ulcer
Polymicrobial infection
Antibiotic resistance
Lytic bacteriophage
ISSN:1940-6029, 1940-6029
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Abstract Diabetic foot ulcers occur as a common complication of diabetes. Healing of the ulcers is largely delayed by the concomitant infection. Antibiotic treatment of infected ulcers is complicated by formation of microbial biofilms , which are often heterogeneous and resistant to antibiotics. Bacteriophage therapy is considered as an additional approach to the treatment of infected wounds. Here, we describe the basic method of application of bacteriophages for treatment of infected diabetic foot ulcers, including ones that are very large.
AbstractList Diabetic foot ulcers occur as a common complication of diabetes. Healing of the ulcers is largely delayed by the concomitant infection. Antibiotic treatment of infected ulcers is complicated by formation of microbial biofilms , which are often heterogeneous and resistant to antibiotics. Bacteriophage therapy is considered as an additional approach to the treatment of infected wounds. Here, we describe the basic method of application of bacteriophages for treatment of infected diabetic foot ulcers, including ones that are very large.
Diabetic foot ulcers occur as a common complication of diabetes. Healing of the ulcers is largely delayed by the concomitant infection. Antibiotic treatment of infected ulcers is complicated by formation of microbial biofilms , which are often heterogeneous and resistant to antibiotics. Bacteriophage therapy is considered as an additional approach to the treatment of infected wounds. Here, we describe the basic method of application of bacteriophages for treatment of infected diabetic foot ulcers, including ones that are very large.Diabetic foot ulcers occur as a common complication of diabetes. Healing of the ulcers is largely delayed by the concomitant infection. Antibiotic treatment of infected ulcers is complicated by formation of microbial biofilms , which are often heterogeneous and resistant to antibiotics. Bacteriophage therapy is considered as an additional approach to the treatment of infected wounds. Here, we describe the basic method of application of bacteriophages for treatment of infected diabetic foot ulcers, including ones that are very large.
Author Kozlova, Yulia N
Tikunova, Nina V
Ganichev, Denis A
Morozova, Vera V
Author_xml – sequence: 1
  givenname: Vera V
  surname: Morozova
  fullname: Morozova, Vera V
  email: morozova@niboch.nsc.ru
  organization: Institute of Chemical Biology and Fundamental Medicine SB RAS, Laboratory of Molecular Microbiology, Lavrentiev Ave. 8, Novosibirsk, 630090, Russian Federation. morozova@niboch.nsc.ru
– sequence: 2
  givenname: Yulia N
  surname: Kozlova
  fullname: Kozlova, Yulia N
  organization: Institute of Chemical Biology and Fundamental Medicine SB RAS, Laboratory of Molecular Microbiology, Lavrentiev Ave. 8, Novosibirsk, 630090, Russian Federation
– sequence: 3
  givenname: Denis A
  surname: Ganichev
  fullname: Ganichev, Denis A
  organization: Railway Clinical Hospital, Str. Vladimirovsky Spusk 2A, Novosibirsk, 630003, Russian Federation
– sequence: 4
  givenname: Nina V
  surname: Tikunova
  fullname: Tikunova, Nina V
  organization: Institute of Chemical Biology and Fundamental Medicine SB RAS, Laboratory of Molecular Microbiology, Lavrentiev Ave. 8, Novosibirsk, 630090, Russian Federation
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Keywords Diabetes
Bacteriophage therapy
Diabetic foot ulcer
Polymicrobial infection
Antibiotic resistance
Lytic bacteriophage
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Snippet Diabetic foot ulcers occur as a common complication of diabetes. Healing of the ulcers is largely delayed by the concomitant infection. Antibiotic treatment of...
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SubjectTerms Bacterial Physiological Phenomena
Bacteriophages - physiology
Diabetic Foot - prevention & control
Humans
Middle Aged
Wound Healing
Wound Infection - microbiology
Wound Infection - prevention & control
Title Bacteriophage Treatment of Infected Diabetic Foot Ulcers
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