Bacteriophage Treatment of Infected Diabetic Foot Ulcers
Diabetic foot ulcers occur as a common complication of diabetes. Healing of the ulcers is largely delayed by the concomitant infection. Antibiotic treatment of infected ulcers is complicated by formation of microbial biofilms , which are often heterogeneous and resistant to antibiotics. Bacteriophag...
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| Veröffentlicht in: | Methods in molecular biology (Clifton, N.J.) Jg. 1693; S. 151 |
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2018
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| Abstract | Diabetic foot ulcers occur as a common complication of diabetes. Healing of the ulcers is largely delayed by the concomitant infection. Antibiotic treatment of infected ulcers is complicated by formation of microbial biofilms , which are often heterogeneous and resistant to antibiotics. Bacteriophage therapy is considered as an additional approach to the treatment of infected wounds. Here, we describe the basic method of application of bacteriophages for treatment of infected diabetic foot ulcers, including ones that are very large. |
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| AbstractList | Diabetic foot ulcers occur as a common complication of diabetes. Healing of the ulcers is largely delayed by the concomitant infection. Antibiotic treatment of infected ulcers is complicated by formation of microbial biofilms , which are often heterogeneous and resistant to antibiotics. Bacteriophage therapy is considered as an additional approach to the treatment of infected wounds. Here, we describe the basic method of application of bacteriophages for treatment of infected diabetic foot ulcers, including ones that are very large. Diabetic foot ulcers occur as a common complication of diabetes. Healing of the ulcers is largely delayed by the concomitant infection. Antibiotic treatment of infected ulcers is complicated by formation of microbial biofilms , which are often heterogeneous and resistant to antibiotics. Bacteriophage therapy is considered as an additional approach to the treatment of infected wounds. Here, we describe the basic method of application of bacteriophages for treatment of infected diabetic foot ulcers, including ones that are very large.Diabetic foot ulcers occur as a common complication of diabetes. Healing of the ulcers is largely delayed by the concomitant infection. Antibiotic treatment of infected ulcers is complicated by formation of microbial biofilms , which are often heterogeneous and resistant to antibiotics. Bacteriophage therapy is considered as an additional approach to the treatment of infected wounds. Here, we describe the basic method of application of bacteriophages for treatment of infected diabetic foot ulcers, including ones that are very large. |
| Author | Kozlova, Yulia N Tikunova, Nina V Ganichev, Denis A Morozova, Vera V |
| Author_xml | – sequence: 1 givenname: Vera V surname: Morozova fullname: Morozova, Vera V email: morozova@niboch.nsc.ru organization: Institute of Chemical Biology and Fundamental Medicine SB RAS, Laboratory of Molecular Microbiology, Lavrentiev Ave. 8, Novosibirsk, 630090, Russian Federation. morozova@niboch.nsc.ru – sequence: 2 givenname: Yulia N surname: Kozlova fullname: Kozlova, Yulia N organization: Institute of Chemical Biology and Fundamental Medicine SB RAS, Laboratory of Molecular Microbiology, Lavrentiev Ave. 8, Novosibirsk, 630090, Russian Federation – sequence: 3 givenname: Denis A surname: Ganichev fullname: Ganichev, Denis A organization: Railway Clinical Hospital, Str. Vladimirovsky Spusk 2A, Novosibirsk, 630003, Russian Federation – sequence: 4 givenname: Nina V surname: Tikunova fullname: Tikunova, Nina V organization: Institute of Chemical Biology and Fundamental Medicine SB RAS, Laboratory of Molecular Microbiology, Lavrentiev Ave. 8, Novosibirsk, 630090, Russian Federation |
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| Keywords | Diabetes Bacteriophage therapy Diabetic foot ulcer Polymicrobial infection Antibiotic resistance Lytic bacteriophage |
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| Snippet | Diabetic foot ulcers occur as a common complication of diabetes. Healing of the ulcers is largely delayed by the concomitant infection. Antibiotic treatment of... |
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| SubjectTerms | Bacterial Physiological Phenomena Bacteriophages - physiology Diabetic Foot - prevention & control Humans Middle Aged Wound Healing Wound Infection - microbiology Wound Infection - prevention & control |
| Title | Bacteriophage Treatment of Infected Diabetic Foot Ulcers |
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