Bacteriophage Treatment of Infected Diabetic Foot Ulcers

Diabetic foot ulcers occur as a common complication of diabetes. Healing of the ulcers is largely delayed by the concomitant infection. Antibiotic treatment of infected ulcers is complicated by formation of microbial biofilms , which are often heterogeneous and resistant to antibiotics. Bacteriophag...

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Bibliographic Details
Published in:Methods in molecular biology (Clifton, N.J.) Vol. 1693; p. 151
Main Authors: Morozova, Vera V, Kozlova, Yulia N, Ganichev, Denis A, Tikunova, Nina V
Format: Journal Article
Language:English
Published: United States 2018
Subjects:
Bacterial Physiological Phenomena
Bacteriophages - physiology
Diabetic Foot - prevention & control
Humans
Middle Aged
Wound Healing
Wound Infection - microbiology
Wound Infection - prevention & control
Diabetes
Bacteriophage therapy
Diabetic foot ulcer
Polymicrobial infection
Antibiotic resistance
Lytic bacteriophage
ISSN:1940-6029, 1940-6029
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Summary:Diabetic foot ulcers occur as a common complication of diabetes. Healing of the ulcers is largely delayed by the concomitant infection. Antibiotic treatment of infected ulcers is complicated by formation of microbial biofilms , which are often heterogeneous and resistant to antibiotics. Bacteriophage therapy is considered as an additional approach to the treatment of infected wounds. Here, we describe the basic method of application of bacteriophages for treatment of infected diabetic foot ulcers, including ones that are very large.
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ISSN:1940-6029
1940-6029
DOI:10.1007/978-1-4939-7395-8_13