Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor [alpha] to gp130 expression: fusing experimental insights and dynamic modelling

Interleukin-6 is a pleiotropic cytokine with high clinical relevance and an important mediator of cellular communication, orchestrating both pro- and anti-inflammatory processes. Interleukin-6-induced signalling is initiated by binding of IL-6 to the IL-6 receptor [alpha] and subsequent binding to t...

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Bibliographic Details

Published in:	Cell communication and signaling Vol. 17; no. 1
Main Authors:	Reeh, Heike, Rudolph, Nadine, Billing, Ulrike, Christen, Henrike, Streif, Stefan, Bullinger, Eric, Schliemann-Bullinger, Monica, Findeisen, Rolf, Schaper, Fred, Huber, Heinrich J, Dittrich, Anna
Format:	Journal Article
Language:	English
Published:	BioMed Central Ltd 17.05.2019
Subjects:	Anti-inflammatory agents Cellular signal transduction Computer simulation Cytokines Inflammation Interleukins Molecular biology
ISSN:	1478-811X, 1478-811X
Online Access:	Get full text
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