Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8.sup.+ T cells

Tissue-resident memory T cells (T.sub.RM cells) are critical for cellular immunity to respiratory pathogens and reside in both the airways and the interstitium. In the present study, we found that the airway environment drove transcriptional and epigenetic changes that specifically regulated the cyt...

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Bibliographic Details

Published in:	Nature immunology Vol. 21; no. 3; pp. 309 - 320
Main Authors:	Hayward, Sarah L, Scharer, Christopher D, Cartwright, Emily K, Takamura, Shiki, Li, Zheng-Rong Tiger, Boss, Jeremy M, Kohlmeier, Jacob E
Format:	Journal Article
Language:	English
Published:	Nature Publishing Group 01.03.2020
Subjects:	Airway (Medicine) CD8 lymphocytes Environmental health Epigenetic inheritance Genetic aspects Health aspects United States
ISSN:	1529-2908
Online Access:	Get full text
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