Inhibition of Trophoblast Cell Invasion by TGFB1, 2, and 3 Is Associated with a Decrease in Active Proteases

Invasion of extravillous trophoblast cells into the uterus in human pregnancy is tightly regulated. The transforming growth factor-beta (TGFB) family has been suggested to play a role in controlling this process. We hypothesized that TGFB1, 2, and 3 would inhibit the invasive capacity of extravillou...

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Bibliographic Details
Published in:	Biology of reproduction Vol. 73; no. 2; pp. 374 - 381
Main Authors:	Lash, Gendie E, Otun, Harry A, Innes, Barbara A, Bulmer, Judith N, Searle, Roger F, Robson, Stephen C
Format:	Journal Article
Language:	English
Published:	Madison, WI Society for the Study of Reproduction 01.08.2005
Subjects:	Apoptosis - physiology Biological and medical sciences Cell Growth Processes - physiology Cell Movement - drug effects Cell Movement - physiology Embryology: invertebrates and vertebrates. Teratology Female Fetal membranes Fundamental and applied biological sciences. Psychology General aspects. Development. Fetal membranes Humans Immunohistochemistry In Vitro Techniques Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Placenta - drug effects Placenta - physiology Pregnancy Protein Isoforms Tissue Inhibitor of Metalloproteinase-1 - metabolism Tissue Inhibitor of Metalloproteinase-3 - metabolism Transforming Growth Factor beta - antagonists & inhibitors Transforming Growth Factor beta - pharmacology Transforming Growth Factor beta - physiology Trophoblasts - cytology Trophoblasts - drug effects Trophoblasts - physiology Urokinase-Type Plasminogen Activator - metabolism Vertebrates: reproduction Trophoblaste Fetal membrane Enzyme pregnancy Invasion Peptidases Reproduction implantation Hydrolases placenta cytokines Inhibition trophoblast
ISSN:	0006-3363, 1529-7268
Online Access:	Get full text
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