A multiplexed chip-based assay system for investigating the functional development of human skeletal myotubes in vitro

•An assay for measuring functional performance of human muscle fibers was developed.•The system provides multiple data points per chip in defined serum-free conditions.•The collected data characterizes the maturation of human muscle cells in vitro.•This system may prove useful for future pre-clinica...

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Bibliographic Details
Published in:	Journal of biotechnology Vol. 185; pp. 15 - 18
Main Authors:	Smith, A.S.T., Long, C.J., Pirozzi, K., Najjar, S., McAleer, C., Vandenburgh, H.H., Hickman, J.J.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 20.09.2014
Subjects:	Assaying atomic force microscopy Biotechnology Body-on-a-chip Cantilevers Cell Culture Techniques - methods Culture Drug Discovery - methods drugs Functional assay High-Throughput Screening Assays - methods Human Humans in vitro studies In vitro testing Microchip Analytical Procedures - methods Microscopy, Atomic Force - methods Multiplexing Muscle Fibers, Skeletal - physiology Muscle, Skeletal - growth & development Muscles myotubes silicon Skeletal muscle Survival Human Cantilevers DETA Body-on-a-chip Functional assay Skeletal muscle
ISSN:	0168-1656, 1873-4863, 1873-4863
Online Access:	Get full text
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