Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease

Analysis of human pathology led Braak to postulate that α-synuclein (α-syn) pathology could spread from the gut to brain via the vagus nerve. Here, we test this postulate by assessing α-synucleinopathy in the brain in a novel gut-to-brain α-syn transmission mouse model, where pathological α-syn pref...

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Bibliographic Details
Published in:	Neuron (Cambridge, Mass.) Vol. 103; no. 4; p. 627
Main Authors:	Kim, Sangjune, Kwon, Seung-Hwan, Kam, Tae-In, Panicker, Nikhil, Karuppagounder, Senthilkumar S, Lee, Saebom, Lee, Jun Hee, Kim, Wonjoong Richard, Kook, Minjee, Foss, Catherine A, Shen, Chentian, Lee, Hojae, Kulkarni, Subhash, Pasricha, Pankaj J, Lee, Gabsang, Pomper, Martin G, Dawson, Valina L, Dawson, Ted M, Ko, Han Seok
Format:	Journal Article
Language:	English
Published:	United States 21.08.2019
Subjects:	alpha-Synuclein - administration & dosage alpha-Synuclein - deficiency alpha-Synuclein - pharmacokinetics alpha-Synuclein - toxicity Animals Axonal Transport Brain Chemistry Dopaminergic Neurons - metabolism Dopaminergic Neurons - pathology Duodenum - innervation Duodenum - metabolism Humans Injections, Intramuscular Lewy Bodies - metabolism Maze Learning Memory Disorders - etiology Mice Mice, Inbred C57BL Mice, Knockout Models, Neurological Muscle, Smooth - innervation Muscle, Smooth - metabolism Nesting Behavior - physiology Parkinsonian Disorders - etiology Parkinsonian Disorders - metabolism Parkinsonian Disorders - prevention & control Parkinsonian Disorders - psychology Phosphorylation Protein Aggregates Protein Processing, Post-Translational Pylorus - innervation Pylorus - metabolism Rotarod Performance Test Vagotomy Vagus Nerve - metabolism Lewy body pathology vagus nerve motor symptoms Braak hypothesis pre-formed fibrils neurodegeneration gut to brain transmission non-motor symptoms Parkinson’s disease α-synuclein
ISSN:	1097-4199, 1097-4199
Online Access:	Get more information
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