Fragment-based screening by protein-detected NMR spectroscopy

Fragment-based drug discovery (FBDD) identifies low molecular weight compounds that can be developed into ligands with high affinity and selectivity for therapeutic targets. Screening fragment libraries (<10,000 molecules) with biophysical techniques against macromolecules provides information ab...

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Podrobná bibliografia
Vydané v:	Methods in enzymology Ročník 690; s. 285
Hlavní autori:	Kerber, Paul J, Nuñez, Raymundo, Jensen, Davin R, Zhou, Angela L, Peterson, Francis C, Hill, R Blake, Volkman, Brian F, Smith, Brian C
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 2023
Predmet:	Binding Sites Drug Discovery - methods Humans Ligands Magnetic Resonance Spectroscopy Nuclear Magnetic Resonance, Biomolecular - methods Proteins Thermostability Chemical shift perturbations Fragment-based drug discovery Difference intensity analysis Python scripts Nuclear magnetic resonance Biophysical techniques Structure–activity relationships K-means clustering Principal component analysis
ISSN:	1557-7988, 1557-7988
On-line prístup:	Zistit podrobnosti o prístupe
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