Fragment-based screening by protein-detected NMR spectroscopy

Fragment-based drug discovery (FBDD) identifies low molecular weight compounds that can be developed into ligands with high affinity and selectivity for therapeutic targets. Screening fragment libraries (<10,000 molecules) with biophysical techniques against macromolecules provides information ab...

Full description

Saved in:

Bibliographic Details
Published in:	Methods in enzymology Vol. 690; p. 285
Main Authors:	Kerber, Paul J, Nuñez, Raymundo, Jensen, Davin R, Zhou, Angela L, Peterson, Francis C, Hill, R Blake, Volkman, Brian F, Smith, Brian C
Format:	Journal Article
Language:	English
Published:	United States 2023
Subjects:	Binding Sites Drug Discovery - methods Humans Ligands Magnetic Resonance Spectroscopy Nuclear Magnetic Resonance, Biomolecular - methods Proteins Thermostability Chemical shift perturbations Fragment-based drug discovery Difference intensity analysis Python scripts Nuclear magnetic resonance Biophysical techniques Structure–activity relationships K-means clustering Principal component analysis
ISSN:	1557-7988, 1557-7988
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!