Aryl hydrocarbon receptor control of adaptive immunity

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that belongs to the family of basic helix-loop-helix transcription factors. Although the AhR was initially recognized as the receptor mediating the pathologic effects of dioxins and other pollutants, the activation of AhR...

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Bibliographic Details
Published in:Pharmacological reviews Vol. 65; no. 4; p. 1148
Main Authors: Quintana, Francisco J, Sherr, David H
Format: Journal Article
Language:English
Published: United States 01.10.2013
Subjects:
Adaptive Immunity
Animals
Autoimmunity
Humans
Receptors, Aryl Hydrocarbon - immunology
Receptors, Aryl Hydrocarbon - metabolism
Signal Transduction
ISSN:1521-0081, 1521-0081
Online Access:Get more information
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Summary:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that belongs to the family of basic helix-loop-helix transcription factors. Although the AhR was initially recognized as the receptor mediating the pathologic effects of dioxins and other pollutants, the activation of AhR by endogenous and environmental factors has important physiologic effects, including the regulation of the immune response. Thus, the AhR provides a molecular pathway through which environmental factors modulate the immune response in health and disease. In this review, we discuss the role of AhR in the regulation of the immune response, the source and chemical nature of AhR ligands, factors controlling production and degradation of AhR ligands, and the potential to target the AhR for therapeutic immunomodulation.
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ISSN:1521-0081
1521-0081
DOI:10.1124/pr.113.007823