BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells

B cell receptor (BCR) engagement induces naive B cells to differentiate and perform critical immune-regulatory functions. Acquisition of functional specificity requires that a cell survive, enter the cell cycle, and proliferate. We establish that quantitatively distinct Ca2+ signals triggered by var...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 31; no. 2; p. 107474
Main Authors:	Berry, Corbett T., Liu, Xiaohong, Myles, Arpita, Nandi, Satabdi, Chen, Youhai H., Hershberg, Uri, Brodsky, Igor E., Cancro, Michael P., Lengner, Christopher J., May, Michael J., Freedman, Bruce D.
Format:	Journal Article
Language:	English
Published:	Elsevier Inc 14.04.2020
Subjects:	apoptosis Bcl-xL c-Myc c-Rel CD40 mTORC1 NFAT nuclear factor kappa B Orai1 STIM1 CD40 Bcl-xL STIM1 c-Myc nuclear factor kappa B c-Rel Orai1 apoptosis mTORC1 NFAT
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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