“Of mice and men”: values and liabilities of the athymic nude mouse model in anticancer drug development

Human tumour xenografts implanted subcutaneously (s.c.) into immunosuppressed mice have played a significant role in preclinical anticancer drug development for the past 25 years. Their use as a predictive indicator of probable clinical activity has been validated for cytotoxics. A retrospective ana...

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Veröffentlicht in:	European journal of cancer (1990) Jg. 40; H. 6; S. 827 - 836
1. Verfasser:	Kelland, L.R.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.04.2004
Schlagworte:	Animals Anti-cancer drug development Antineoplastic Agents - therapeutic use Athymic nude mouse model Disease Models, Animal Drug Design Drug Screening Assays, Antitumor - methods Human tumour xenografts Humans Limitations Mice Mice, Nude Mice, SCID Neoplasm Transplantation Neoplasms - drug therapy Review Transplantation, Heterologous Limitations Review Athymic nude mouse model Anti-cancer drug development Human tumour xenografts
ISSN:	0959-8049, 1879-0852
Online-Zugang:	Volltext
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