Comparative analysis of human and mouse 3′ Igh regulatory regions identifies distinctive structural features

Immunoglobulin heavy chain ( Igh) locus rearrangements are controlled in part by an ∼30 kb complex 3′ regulatory region located 3′ of Cα: this region contains several enhancers. We report here the comparison of the genomic sequences of the 3′ regulatory region and further downstream sequences from m...

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Bibliographic Details
Published in:	Molecular immunology Vol. 42; no. 5; pp. 605 - 615
Main Authors:	Sepulveda, Manuel A., Garrett, Francine E., Price-Whelan, Alexa, Birshtein, Barbara K.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.03.2005
Subjects:	3' Untranslated Regions 3′ Untranslated regions/immunology Animals B-lymphocytes/immunology Base Sequence Chromosomes, Artificial, Bacterial - genetics Conserved sequence DNA - genetics Enhancer elements (genetics)/immunology Evolution Evolution, Molecular Gene Rearrangement, B-Lymphocyte Genes, Immunoglobulin Genes, Regulator Heavy-chain/genetics Human Humans Immunoglobulins Mice Molecular Molecular sequence data Multigene Family Nucleic acid Pan troglodytes Phylogeny Polymorphism, Restriction Fragment Length Rats Regulatory sequences Repetitive Sequences, Nucleic Acid Reverse Transcriptase Polymerase Chain Reaction Species Specificity Enhancer elements (genetics)/immunology Human 3′ Untranslated regions/immunology Immunoglobulins Rats Regulatory sequences B-lymphocytes/immunology Phylogeny Molecular Conserved sequence Heavy-chain/genetics Molecular sequence data Evolution Mice Nucleic acid
ISSN:	0161-5890, 1872-9142
Online Access:	Get full text
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