The consistency and influence of environmental and animal factors on exhaled breath condensate hydrogen peroxide, pH and leukotriene B4 in horses

•Exhaled breath condensate (EBC) analysis is a non-invasive method to assess the lower respiratory tract.•Intra- and inter-day consistency for both EBC H2O2 and pH in horses were adequate.•EBC H2O2 was influenced by ambient temperature, humidity, collection location and time of day.•EBC pH was influ...

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Vydáno v:The veterinary journal (1997) Ročník 226; s. 46 - 50
Hlavní autoři: du Preez, S., Raidal, S.L., Doran, G.S., Nielsen, S.G., Hughes, K.J.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Elsevier Ltd 01.08.2017
Témata:
ambient temperature
biomarkers
condensates
EBC biomarker
Equine
H2O2
horses
humidity
hydrogen peroxide
Leukotriene B4
Respiratory
respiratory rate
Equine
Respiratory
Leukotriene B4
EBC biomarker
H2O2
ISSN:1090-0233, 1532-2971, 1532-2971
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Shrnutí:•Exhaled breath condensate (EBC) analysis is a non-invasive method to assess the lower respiratory tract.•Intra- and inter-day consistency for both EBC H2O2 and pH in horses were adequate.•EBC H2O2 was influenced by ambient temperature, humidity, collection location and time of day.•EBC pH was influenced by respiratory rate during EBC collection and ambient temperature.•EBC LTB4 had poor intra- and inter-day consistency. This study was performed to determine the consistency of exhaled breath condensate (EBC) hydrogen peroxide (H2O2), pH and leukotriene B4 (LTB4) measurements in asymptomatic horses and to define the influence of environmental and animal factors on these variables. Intra- and inter-day consistency for both H2O2 and pH measurements were adequate, with intraclass correlation coefficients ≥0.8, whereas the consistency for LTB4 was poor. H2O2 was influenced by ambient temperature (TA), humidity, time of day and collection location (all P<0.01), while pH was influenced by respiratory rate during EBC collection and TA (both P<0.001). The consistency of EBC H2O2 and pH measurements may be sufficient for use as diagnostic biomarkers in horses. However, the influence of identified environmental and animal factors should be considered.
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ISSN:1090-0233
1532-2971
1532-2971
DOI:10.1016/j.tvjl.2017.07.005