A rare NAB2ex6::STAT6ex3 fusion identified in a large pelvic epithelioid and cystic high-risk solitary fibrous tumor (SFT)
Solitary Fibrous Tumour (SFT) is a fibroblastic mesenchymal neoplasm with variable clinical behaviour with a genetic hallmark of recurrent fusion of NAB2 and STAT6 genes. More than 40 fusion variants have been reported and the NAB2ex6::STAT6ex16/17 groups have been found to carry significant higher...
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| Veröffentlicht in: | Human Pathology Reports Jg. 42; S. 300806 |
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01.11.2025
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| Abstract | Solitary Fibrous Tumour (SFT) is a fibroblastic mesenchymal neoplasm with variable clinical behaviour with a genetic hallmark of recurrent fusion of NAB2 and STAT6 genes. More than 40 fusion variants have been reported and the NAB2ex6::STAT6ex16/17 groups have been found to carry significant higher risk of recurrence. We reported here a rare NAB2ex6::STAT6ex3 fusion found in a large pelvic epithelioid and cystic high risk SFT in a 65-year-old women. Significantly the molecular findings in our patient correlate with the patient’s clinical-pathological high-risk features, expanding the landscape of our knowledge of SFT. |
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| AbstractList | Solitary Fibrous Tumour (SFT) is a fibroblastic mesenchymal neoplasm with variable clinical behaviour with a genetic hallmark of recurrent fusion of NAB2 and STAT6 genes. More than 40 fusion variants have been reported and the NAB2ex6::STAT6ex16/17 groups have been found to carry significant higher risk of recurrence. We reported here a rare NAB2ex6::STAT6ex3 fusion found in a large pelvic epithelioid and cystic high risk SFT in a 65-year-old women. Significantly the molecular findings in our patient correlate with the patient’s clinical-pathological high-risk features, expanding the landscape of our knowledge of SFT. AbstractSolitary Fibrous Tumour (SFT) is a fibroblastic mesenchymal neoplasm with variable clinical behaviour with a genetic hallmark of recurrent fusion of NAB2 and STAT6 genes. More than 40 fusion variants have been reported and the NAB2ex6::STAT6ex16/17 groups have been found to carry significant higher risk of recurrence. We reported here a rare NAB2ex6::STAT6ex3 fusion found in a large pelvic epithelioid and cystic high risk SFT in a 65-year-old women. Significantly the molecular findings in our patient correlate with the patient’s clinical-pathological high-risk features, expanding the landscape of our knowledge of SFT. |
| ArticleNumber | 300806 |
| Author | Riedlinger, Gregory M. Li, Lin Stephenson, Ruth D. Nandi, Jhuma Ghodoussipour, Saum Peeples, Mary Gottshall, Lauren Becker, Murray |
| Author_xml | – sequence: 1 givenname: Jhuma surname: Nandi fullname: Nandi, Jhuma organization: Department of Pathology and Laboratory Medicine, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA – sequence: 2 givenname: Mary surname: Peeples fullname: Peeples, Mary organization: Department of Pathology and Laboratory Medicine, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA – sequence: 3 givenname: Ruth D. surname: Stephenson fullname: Stephenson, Ruth D. organization: Section of Gynecologic Oncology, Rutgers Cancer Institute, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA – sequence: 4 givenname: Lauren surname: Gottshall fullname: Gottshall, Lauren organization: Section of Gynecologic Oncology, Rutgers Cancer Institute, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA – sequence: 5 givenname: Saum surname: Ghodoussipour fullname: Ghodoussipour, Saum organization: Section of Urologic Oncology, Rutgers Cancer Institute, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA – sequence: 6 givenname: Murray surname: Becker fullname: Becker, Murray organization: Department of Radiology, Rutgers Cancer Institute, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA – sequence: 7 givenname: Gregory M. surname: Riedlinger fullname: Riedlinger, Gregory M. organization: Department of Pathology and Laboratory Medicine, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA – sequence: 8 givenname: Lin surname: Li fullname: Li, Lin email: ll1109@rwjms.rutgers.edu, Lin.Li@rwjbh.org organization: Department of Pathology and Laboratory Medicine, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA |
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| DOI | 10.1016/j.hpr.2025.300806 |
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| Keywords | Solitary fibrous tumor (SFT) Exon NAB2 STAT6 Pelvic Fusion Epithelioid |
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| SubjectTerms | Epithelioid Exon Fusion NAB2 Pathology Pelvic Solitary fibrous tumor (SFT) STAT6 |
| Title | A rare NAB2ex6::STAT6ex3 fusion identified in a large pelvic epithelioid and cystic high-risk solitary fibrous tumor (SFT) |
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