Quantitative determination of potential genotoxic impurities in metformin hydrochloride and empagliflozin tablets through ultra-performance liquid chromatographymass spectrometry

An increasing number of drug research institutions consider genotoxic impurity research a core task in drug research and development. Peroxides in drugs may directly or indirectly attack and damage cell DNA, posing a potential carcinogenic risk to the human body. Currently, the literature only studi...

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Bibliographic Details
Published in:	Journal of pharmaceutical and biomedical analysis Vol. 241; p. 116000
Main Authors:	Xiao, Tingyu, Hu, Xin, Chen, Yucheng, Lin, Huaqing
Format:	Journal Article
Language:	English
Published:	England Elsevier B.V 15.04.2024
Subjects:	Benzhydryl Compounds Chromatography, High Pressure Liquid - methods Empagliflozin Genotoxic impurity Glucosides Humans Metformin Metformin - analysis Peroxide Peroxides Spectrum Analysis Tablets UPLC3MS/MS Empagliflozin Metformin UPLC3MS/MS Peroxide Genotoxic impurity
ISSN:	0731-7085, 1873-264X, 1873-264X
Online Access:	Get full text
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