Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer

The long non-coding RNA PVT1 (lncRNA PVT1) has been reported to act as an oncogenic regulator of several cancers. However, its expression and function in gallbladder cancer (GBC) remain largely unknown. In situ hybridization (ISH) and quantitative real-time PCR (qPCR) were performed to detect the ex...

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Bibliographic Details
Published in:	Molecular cancer Vol. 18; no. 1; pp. 33 - 16
Main Authors:	Chen, Jianan, Yu, Yan, Li, Hua, Hu, Qiuyue, Chen, Xiaolong, He, Yuting, Xue, Chen, Ren, Fang, Ren, Zhigang, Li, Juan, Liu, Liwen, Duan, Zhenfeng, Cui, Guangying, Sun, Ranran
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 02.03.2019 Springer Nature B.V BioMed Central BMC
Subjects:	Adolescent Adult Animals Biotin Cancer Cancer metastasis Carcinoma - genetics Carcinoma - metabolism Carcinoma - mortality Carcinoma - pathology Cell growth Cell Line, Tumor Cell lines Cell migration Cell Movement Cell Proliferation Cell survival Cholecystokinin Development and progression Diagnosis Female Gallbladder Gallbladder cancer Gallbladder Neoplasms - genetics Gallbladder Neoplasms - metabolism Gallbladder Neoplasms - mortality Gallbladder Neoplasms - pathology Gastric cancer Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Glucose Glucose - metabolism Glycolysis - genetics Hexokinase Hexokinase - genetics Hexokinase - metabolism HK2 Humans Hybridization Immunohistochemistry Immunoprecipitation Journalists Liver cancer Long non-coding RNA Luciferase Lymphatic Metastasis Male Medical prognosis Metabolism Metastases Metastasis Mice MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miR-143 Neoplasm Staging Non-coding RNA Novels Prostate cancer PVT1 RNA RNA, Long Noncoding - antagonists & inhibitors RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal Transduction Studies Survival Analysis Therapeutic applications Tumorigenesis Tumors Wound care Wound healing Xenograft Model Antitumor Assays Xenografts China miR-143 PVT1 Gallbladder cancer HK2 Long non-coding RNA
ISSN:	1476-4598, 1476-4598
Online Access:	Get full text
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