Smart H2S‐Triggered/Therapeutic System (SHTS)‐Based Nanomedicine

Hydrogen sulfide (H2S) is of vital importance in several biological and physical processes. The significance of H2S‐specific detection and monitoring is emphasized by its elevated levels in various diseases such as cancer. Nanotechnology enhances the performance of chemical sensing nanoprobes due to...

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Published in:Advanced science Vol. 6; no. 22; pp. 1901724 - n/a
Main Authors: Chen, Weiyu, Ni, Dalong, Rosenkrans, Zachary T., Cao, Tianye, Cai, Weibo
Format: Journal Article
Language:English
Published: Hoboken John Wiley and Sons Inc 01.11.2019
Wiley
Subjects:
gas delivery
H2S‐specific detection
H2S‐triggered therapy
hydrogen sulfide
novel nanoplatforms
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ISSN:2198-3844, 2198-3844
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Abstract Hydrogen sulfide (H2S) is of vital importance in several biological and physical processes. The significance of H2S‐specific detection and monitoring is emphasized by its elevated levels in various diseases such as cancer. Nanotechnology enhances the performance of chemical sensing nanoprobes due to the enhanced efficiency and sensitivity. Recently, extensive research efforts have been dedicated to developing novel smart H2S‐triggered/therapeutic system (SHTS) nanoplatforms for H2S‐activated sensing, imaging, and therapy. Herein, the latest SHTS‐based nanomaterials are summarized and discussed in detail. In addition, therapeutic strategies mediated by endogenous H2S as a trigger or exogenous H2S delivery are also included. A comprehensive understanding of the current status of SHTS‐based strategies will greatly facilitate innovation in this field. Lastly, the challenges and key issues related to the design and development of SHTS‐based nanomaterials (e.g., morphology, surface modification, therapeutic strategies, appropriate application, and selection of nanomaterials) are outlined. H2S‐specific nanoagents are of vital importance in detecting endogenous and exogenous H2S gas. The recent developments of these smart H2S‐triggered/therapeutic systems (SHTSs) are summarized. Additionally, the challenge faced, and the principals involved, are further discussed for future H2S‐nanoprobe designs.
AbstractList Hydrogen sulfide (H2S) is of vital importance in several biological and physical processes. The significance of H2S-specific detection and monitoring is emphasized by its elevated levels in various diseases such as cancer. Nanotechnology enhances the performance of chemical sensing nanoprobes due to the enhanced efficiency and sensitivity. Recently, extensive research efforts have been dedicated to developing novel smart H2S-triggered/therapeutic system (SHTS) nanoplatforms for H2S-activated sensing, imaging, and therapy. Herein, the latest SHTS-based nanomaterials are summarized and discussed in detail. In addition, therapeutic strategies mediated by endogenous H2S as a trigger or exogenous H2S delivery are also included. A comprehensive understanding of the current status of SHTS-based strategies will greatly facilitate innovation in this field. Lastly, the challenges and key issues related to the design and development of SHTS-based nanomaterials (e.g., morphology, surface modification, therapeutic strategies, appropriate application, and selection of nanomaterials) are outlined.Hydrogen sulfide (H2S) is of vital importance in several biological and physical processes. The significance of H2S-specific detection and monitoring is emphasized by its elevated levels in various diseases such as cancer. Nanotechnology enhances the performance of chemical sensing nanoprobes due to the enhanced efficiency and sensitivity. Recently, extensive research efforts have been dedicated to developing novel smart H2S-triggered/therapeutic system (SHTS) nanoplatforms for H2S-activated sensing, imaging, and therapy. Herein, the latest SHTS-based nanomaterials are summarized and discussed in detail. In addition, therapeutic strategies mediated by endogenous H2S as a trigger or exogenous H2S delivery are also included. A comprehensive understanding of the current status of SHTS-based strategies will greatly facilitate innovation in this field. Lastly, the challenges and key issues related to the design and development of SHTS-based nanomaterials (e.g., morphology, surface modification, therapeutic strategies, appropriate application, and selection of nanomaterials) are outlined.
Hydrogen sulfide (H2S) is of vital importance in several biological and physical processes. The significance of H2S‐specific detection and monitoring is emphasized by its elevated levels in various diseases such as cancer. Nanotechnology enhances the performance of chemical sensing nanoprobes due to the enhanced efficiency and sensitivity. Recently, extensive research efforts have been dedicated to developing novel smart H2S‐triggered/therapeutic system (SHTS) nanoplatforms for H2S‐activated sensing, imaging, and therapy. Herein, the latest SHTS‐based nanomaterials are summarized and discussed in detail. In addition, therapeutic strategies mediated by endogenous H2S as a trigger or exogenous H2S delivery are also included. A comprehensive understanding of the current status of SHTS‐based strategies will greatly facilitate innovation in this field. Lastly, the challenges and key issues related to the design and development of SHTS‐based nanomaterials (e.g., morphology, surface modification, therapeutic strategies, appropriate application, and selection of nanomaterials) are outlined. H2S‐specific nanoagents are of vital importance in detecting endogenous and exogenous H2S gas. The recent developments of these smart H2S‐triggered/therapeutic systems (SHTSs) are summarized. Additionally, the challenge faced, and the principals involved, are further discussed for future H2S‐nanoprobe designs.
Hydrogen sulfide (H2S) is of vital importance in several biological and physical processes. The significance of H2S‐specific detection and monitoring is emphasized by its elevated levels in various diseases such as cancer. Nanotechnology enhances the performance of chemical sensing nanoprobes due to the enhanced efficiency and sensitivity. Recently, extensive research efforts have been dedicated to developing novel smart H2S‐triggered/therapeutic system (SHTS) nanoplatforms for H2S‐activated sensing, imaging, and therapy. Herein, the latest SHTS‐based nanomaterials are summarized and discussed in detail. In addition, therapeutic strategies mediated by endogenous H2S as a trigger or exogenous H2S delivery are also included. A comprehensive understanding of the current status of SHTS‐based strategies will greatly facilitate innovation in this field. Lastly, the challenges and key issues related to the design and development of SHTS‐based nanomaterials (e.g., morphology, surface modification, therapeutic strategies, appropriate application, and selection of nanomaterials) are outlined. H2S‐specific nanoagents are of vital importance in detecting endogenous and exogenous H2S gas. The recent developments of these smart H2S‐triggered/therapeutic systems (SHTSs) are summarized. Additionally, the challenge faced, and the principals involved, are further discussed for future H2S‐nanoprobe designs.
Abstract Hydrogen sulfide (H2S) is of vital importance in several biological and physical processes. The significance of H2S‐specific detection and monitoring is emphasized by its elevated levels in various diseases such as cancer. Nanotechnology enhances the performance of chemical sensing nanoprobes due to the enhanced efficiency and sensitivity. Recently, extensive research efforts have been dedicated to developing novel smart H2S‐triggered/therapeutic system (SHTS) nanoplatforms for H2S‐activated sensing, imaging, and therapy. Herein, the latest SHTS‐based nanomaterials are summarized and discussed in detail. In addition, therapeutic strategies mediated by endogenous H2S as a trigger or exogenous H2S delivery are also included. A comprehensive understanding of the current status of SHTS‐based strategies will greatly facilitate innovation in this field. Lastly, the challenges and key issues related to the design and development of SHTS‐based nanomaterials (e.g., morphology, surface modification, therapeutic strategies, appropriate application, and selection of nanomaterials) are outlined.
Author Rosenkrans, Zachary T.
Ni, Dalong
Cao, Tianye
Cai, Weibo
Chen, Weiyu
AuthorAffiliation 2 Department of Pharmaceutical Sciences University of Wisconsin‐Madison Madison WI 53705 USA
1 Departments of Radiology and Medical Physics University of Wisconsin‐Madison Madison WI 53705 USA
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Snippet Hydrogen sulfide (H2S) is of vital importance in several biological and physical processes. The significance of H2S‐specific detection and monitoring is...
Hydrogen sulfide (H2S) is of vital importance in several biological and physical processes. The significance of H2S-specific detection and monitoring is...
Abstract Hydrogen sulfide (H2S) is of vital importance in several biological and physical processes. The significance of H2S‐specific detection and monitoring...
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StartPage 1901724
SubjectTerms gas delivery
H2S‐specific detection
H2S‐triggered therapy
hydrogen sulfide
novel nanoplatforms
Review
Reviews
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Title Smart H2S‐Triggered/Therapeutic System (SHTS)‐Based Nanomedicine
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